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LAI versus oral antipsychotic maintenance treatment of schizophrenia: A case-control study on subjective experience of treatment

Published online by Cambridge University Press:  23 March 2020

F. Pietrini ,
M. Spadafora ,
L. Tatini ,
G.A. Talamba ,
E. Burchi ,
E. Calderani ,
S. Gemignani ,
L. Mallardo ,
C. Andrisano  and
G. Boncompagni
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F. Pietrini*
Affiliation:
University of Florence, Department of Neuroscience, Psychology, Drug Research and Child Health, section of Neuroscience, Florence, Italy
M. Spadafora
Affiliation:
University of Florence, Department of Neuroscience, Psychology, Drug Research and Child Health, section of Neuroscience, Florence, Italy
L. Tatini
Affiliation:
University of Florence, Department of Neuroscience, Psychology, Drug Research and Child Health, section of Neuroscience, Florence, Italy
G.A. Talamba
Affiliation:
University of Florence, Department of Neuroscience, Psychology, Drug Research and Child Health, section of Neuroscience, Florence, Italy
E. Burchi
Affiliation:
University of Florence, Department of Neuroscience, Psychology, Drug Research and Child Health, section of Neuroscience, Florence, Italy
E. Calderani
Affiliation:
University of Florence, Department of Neuroscience, Psychology, Drug Research and Child Health, section of Neuroscience, Florence, Italy
S. Gemignani
Affiliation:
University of Florence, Department of Neuroscience, Psychology, Drug Research and Child Health, section of Neuroscience, Florence, Italy
L. Mallardo
Affiliation:
University of Florence, Department of Neuroscience, Psychology, Drug Research and Child Health, section of Neuroscience, Florence, Italy
C. Andrisano
Affiliation:
University of Bologna, Department of Biomedical and Neuromotor Sciences, Bologna, Italy
G. Boncompagni
Affiliation:
Local Health Trust of Bologna, Department of Mental Health and Substance Abuse, Bologna, Italy
M. Manetti
Affiliation:
Campo del Vescovo Union, Therapeutic Psychiatric Community, La Spezia, Italy
A. Ballerini
Affiliation:
University of Florence, Department of Neuroscience, Psychology, Drug Research and Child Health, section of Neuroscience, Florence, Italy
V. Ricca
Affiliation:
University of Florence, Department of Neuroscience, Psychology, Drug Research and Child Health, section of Neuroscience, Florence, Italy
*
*Corresponding author.

Abstract

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Introduction

Limited research has been devoted to the subjective impact of switching antipsychotic maintenance treatment (AMT) from oral to LAI formulation in schizophrenia.

Objective

To compare LAI AMT with oral AMT in terms of subjective experience of treatment, taking into account the effects on psychopathology.

Methods

Twenty outpatients (7 males, mean age 40.55 ± 11.00 years) with remitted schizophrenia treated with either olanzapine or paliperidone and switching from oral to LAI AMT were recruited before the switch (LAI-AMT group). A group of 20 remitted schizophrenic subjects with oral AMT and matched for the main socio-demographic, clinical and treatment variables made up the controls (oral-AMT group). All participants were assessed by means of the PANSS and of the SWN-K at baseline (T0) and after 6 months (T1).

Results

Between T0 and T1, general psychopathology of the PANSS and all but one of the SWN-K dimensions (except for “social integration”), showed significantly higher percent improvements in the LAI-AMT group compared to the oral-AMT group. After 6 months (T1), the LAI-AMT group showed significantly lower PANSS total and general psychopathology scores, as well as higher mean score of perceived “mental functioning” compared to the oral-AMT group. Item analysis of the general PANSS at T1 showed significant differences between the two groups in anxiety, tension, depression, guilt feelings, poor attention, and active social avoidance.

Conclusions

Our data on switching from oral to LAI AMT in remitted schizophrenia suggest a better efficacy of the latter in terms of improvement of general psychopathology and subjective experience of treatment.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
EV1180
Information
European Psychiatry , Volume 33 , Issue S1: Abstracts of the 24th European Congress of Psychiatry , March 2016 , pp. S583
Copyright
Copyright © European Psychiatric Association 2016
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