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Major depression, cardiovascular risk factors and the Omega-3 index

Published online by Cambridge University Press:  16 April 2020

T.C. Baghai ,
G. Varallo-Bedarida ,
C. Born ,
S. Haefner ,
C. Schüle ,
D. Eser ,
R. Rupprecht ,
B. Bondy  and
C. von Schacky
T.C. Baghai
Affiliation:
Psychiatry and Psychotherapy, Munich, Germany
G. Varallo-Bedarida
Affiliation:
Preventive Cardiology, LMU-Munich, Munich, Germany
C. Born
Affiliation:
Psychiatry and Psychotherapy, Munich, Germany
S. Haefner
Affiliation:
Psychiatry and Psychotherapy, Munich, Germany
C. Schüle
Affiliation:
Psychiatry and Psychotherapy, Munich, Germany
D. Eser
Affiliation:
Psychiatry and Psychotherapy, Munich, Germany
R. Rupprecht
Affiliation:
Psychiatry and Psychotherapy, Munich, Germany
B. Bondy
Affiliation:
Psychiatry and Psychotherapy, Munich, Germany
C. von Schacky
Affiliation:
Preventive Cardiology, LMU-Munich, Munich, Germany

Abstract

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Introduction

Cardiovascular disease (CVD) and major depressive disorders (MDD) are frequent diseases worldwide with a high comorbidity rate. Omega-3 fatty acids have been suggested as disease modulators for both CVD and MDD.

Objective and aims

Therefore, we studied whether polyunsaturated fatty acids and the Omega-3 Index may represent markers for assessment of the cardiovascular risk in physically healthy patients suffering from MDD.

Methods

Case-control study in 166 adults (86 MDD patients without CVD, 80 matched healthy controls). Baseline examinations included depression ratings, conventional cardiovascular risk factors, fatty acid, and interleukin-6 determinations.

Results

Several conventional risk factors were more prevalent in MDD patients. The Omega-3 Index and individual omega-3 fatty acids were significantly lower in MDD patients. An Omega-3 Index < 4% was associated with high concentrations of the proinflammatory cytokine IL-6.

Conclusion

Conventional cardiovascular risk factors, the Omega-3 Index and IL-6 indicated an elevated cardiovascular risk profile in MDD patients currently free of CVD. Our results support the employment of strategies to reduce the cardiovascular risk in yet cardiovascularly healthy MDD patients by targeting conventional risk factors and the Omega-3 Index.

Type
P02-09
Information
European Psychiatry , Volume 26 , Issue S2: Abstracts of the 19th European Congress of Psychiatry , March 2011 , pp. 603
Copyright
Copyright © European Psychiatric Association2011
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