The possible role of mothers’ thrombophilic predisposition as a risk factor mental and motor delay in toddlers

Abstract

Introduction

Inherited thrombophilia is described as a risk factor for burdened obstetrical history. But the relashionships between mothers’ thrombophilic predisposion (MTP) and mental status in their children is not investigated thoroughly.

Objectives

To investigate the mental and motor neonates’ status, born from MTP.

Methods

Case-control study. Thirty-seven children born from MTP were assessed at 1, 3, 6 and 12-month (1st group). MTP carried more than 5 thrombophilic single nucleotide polymorphisms and had burdened obstetrical history; 47 neonates with clear mothers’ obstetrical history and 2 and less SNPs (2nd group); informed consent form. The quantity of term and preterm neonates were equal in groups.

Results

We found the neonates from both group were comparable under the 6-month age (table). But in year-old children mental and/or motor delays were more frequent in 1^st group despite on comparable level of paresis and brain ultrasound data. There were no thrombotic episodes in children in 1st group.

Conclusions

There were no direct link between MTP and neurological outcomes in children: paresis and ischemic lesions in brain were not differ in groups. Confirmed MTP can cause mental and motor delays to year-old period, milestones must be supervised thoroughly until 3 y.o.

Disclosure of interest

The authors have not supplied their declaration of competing interest.