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Psychopathology of the self and the altered cortical midline structures in psychiatric disorders – a marriage?

Published online by Cambridge University Press:  23 March 2020

G. Northoff
G. Northoff*
Affiliation:
University of Ottawa, Institute of Mental Research, Ottawa, Canada

Abstract

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The self is central in our mental life and disturbances of the self-figure most prominently in psychopathological symptoms. The cortical midline structures (CMS) have been associated with self-related processing and its changes in schizophrenia, depression and other psychiatric disorders. However, the exact neuronal mechanisms underlying self-related processing in CMS and its changes in psychiatric disorders remain unclear. Especially the neural overlap between high resting state activity levels and self-related processing in CMS is rather puzzling. I present recent data on the rest-self overlap in healthy subjects showing that resting state activity in CMS can predict self-relatedness. The implications for psychological symptoms as in depression and schizophrenia are pointed out.

Disclosure of interest

The author has not supplied his declaration of competing interest.

Type
S86
Information
European Psychiatry , Volume 33 , Issue S1: Abstracts of the 24th European Congress of Psychiatry , March 2016 , pp. S45
Copyright
Copyright © European Psychiatric Association 2016
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