PW01-93 - The Effects On The Level Of Intestinal Endotoxemia In Alzheimer Disease Rats

Abstract

Objective

The objective of the present study was to explore the level of intestinal endotoxemia (IETM) in the model of Alzheimer disease's rats which were established by D-galactose and aluminum trichloride (AlCl₃).

Methods

Adult Wistar rats were subjected to 90 days of intraperitoneal injection with D-galactose and AlCl₃ to establish the Alzheimer disease's model. After the administration, the study and memory ability of the Alzheimer disease's rats were observed by Morris water maze; The level of Lipopolysaccharide (LPS) in the sera of Alzheimer disease's rats was determined by tachypleus amebocyte lysate method; The level of tumor necrosis factor-α (TNF-α) and interleukin-1 (IL-1) in the sera of Alzheimer disease's rats were determined by radioimmunity method;

Results

Compared with the normal control, the level of LPS, TNF-α and IL-1 in the sera of Alzheimer disease's rats were markedly increased (P< 0.01).

Conclusions

The model of Alzheimer disease's rats which were established by D-galactose and AlCl₃ is accompanied IETM.