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Quetiapine XR reduce impulsivity and dissociation in a sample of alcoholic patients

Published online by Cambridge University Press:  23 March 2020

M. Godio ,
M. Preve ,
N.E. Suardi ,
E. Bolla ,
R.A. Colombo  and
R. Traber
M. Godio
Affiliation:
Sociopsychiatric Organization, Psychiatric Clinic, Mendrisio, Switzerland
N.E. Suardi
Affiliation:
Sociopsychiatric Organization, Psychiatric Clinic, Mendrisio, Switzerland
E. Bolla
Affiliation:
Sociopsychiatric Organization, Psychiatric Clinic, Mendrisio, Switzerland
R.A. Colombo
Affiliation:
Sociopsychiatric Organization, Psychiatric Clinic, Mendrisio, Switzerland
R. Traber
Affiliation:
Sociopsychiatric Organization, Psychiatric Clinic, Mendrisio, Switzerland

Abstract

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Introduction

Alcohol dependence (AD) is a major public health problem. Currently, three drugs for the treatment of AD have been approved: acamprosate, disulfiram and oral naltrexone. Quetiapine XR is an atypical antipsychotic has been shown to be a promising medication for the treatment of alcoholism [1,2]. The aim of our study is evaluate quetiapine efficacy on impulsivity in a sample of alcoholic patients.

Method

A sample of alcoholic patients (n = 40) was assessed at the entrance and 2 months with: SCID-P, Brief-Temps, BIS-11, GSR, BPRS, SCI-DER, and CGI. The medium dosage of quetiapine is 300 mg.

Results

Using the last observation carried forward, the mean total BIS score decreased from 60.8 at baseline to 40.2 at the final visit (P = .03). More pronounced improvement was observed in motor impulsiveness (P < .03) and attentional impulsiveness (P < .05) compared with non-planning impulsiveness (P = .09). We observed an improvement in SCI-DER total score (P = .02), in particular in derealization (P = .03) and autopsychic depersonalization (P = .04). A mean weight gain of 4.8 kg was observed. There is not significant different related to the different affective temperament.

Discussion and conclusion

Analyses revealed a significant effect of Quetiapine XR in improving impulsivity and dissociation, in particular motor and attentional impulsiveness, derealization and autopsychic depersonalization. Moreover, an improvement of dissociative symptoms is probably connected with the blockade of postsynaptic 5-HT1A receptors [3]. Methodological limitations, clinical implications and suggestions for future research directions are considered.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
EV83
Information
European Psychiatry , Volume 33 , Issue S1: Abstracts of the 24th European Congress of Psychiatry , March 2016 , pp. S312 - S313
Copyright
Copyright © European Psychiatric Association 2016

References

Moallem, N. SSP 2012Google Scholar
Barzman, D.H., et al. SSP 2006Google Scholar
Millan, M.J. SSP 2000Google Scholar
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