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Research progress of metabonomics of blood endogenous small molecules in depression

Published online by Cambridge University Press:  13 August 2021

Y. Zhang ,
J. Ding  and
X. Cui
Y. Zhang
Affiliation:
Pharmacy Lab, Xi’an Mental Health Center, Xi’an, China
J. Ding*
Affiliation:
Pharmacy Lab, Xi’an Mental Health Center, Xi’an, China
X. Cui
Affiliation:
Pharmacy Lab, Xi’an Mental Health Center, Xi’an, China
*
*Corresponding author.

Abstract

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Introduction

Depression (MDD) is a serious mental illness, which greatly affects the quality of life of patients. Nowadays, the clinical diagnosis of MDD lacks sufficient objective basis, and the effect of drug treatment is unsatisfactory. Therefore, biomarkers are very important for the risk prediction, classification, diagnosis and prognosis of MDD.

Objectives

Research progress of metabonomics of blood endogenous small molecules in depression

Methods

Metabonomics is a newly developed discipline after genomics and proteomics, and is an important part of system biology. Metabonomics provides a new approach to explore the etiology, mechanism, prognosis and screening potential biomarkers of MDD. Blood contains almost all the small molecule metabolites in the body. The changes of metabolites in blood can represent the changes of metabolites in other body fluids. Moreover, this sample is easy to obtain and has less trauma, so it is the most common biological sample in clinical detection.

Results

At present, there are many studies on the metabonomics of endogenous small molecules in MDD blood, which provides the possibility for further screening of MDD related biomarkers.

Conclusions

In this paper, the research progress of related biomarkers in MDD blood is reviewed.

Disclosure

No significant relationships.

Keywords

metabonomicsblood endogenous small moleculesDepression
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S776 - S777
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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