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Self-stigma, Hope, Dissociation, and Personality Features in Treatment of Depressive Inpatients Resistant to Pharmacotherapy

Published online by Cambridge University Press:  23 March 2020

J. Prasko ,
M. Ociskova ,
Z. Sigmundova ,
P. Kasalova ,
A. Grambal ,
M. Holubova ,
M. Marackova ,
K. Vrbova ,
K. Latalova  and
M. Slepecky
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J. Prasko
Affiliation:
University Hospital Olomouc, Department of Psychiatry, Olomouc, Czech Republic
M. Ociskova
Affiliation:
University Hospital Olomouc, Department of Psychiatry, Olomouc, Czech Republic
Z. Sigmundova
Affiliation:
University Hospital Olomouc, Department of Psychiatry, Olomouc, Czech Republic
P. Kasalova
Affiliation:
University Hospital Olomouc, Department of Psychiatry, Olomouc, Czech Republic
A. Grambal
Affiliation:
University Hospital Olomouc, Department of Psychiatry, Olomouc, Czech Republic
M. Holubova
Affiliation:
Department of Psychiatry, Hospital Liberec, Liberec, Czech Republic
M. Marackova
Affiliation:
University Hospital Olomouc, Department of Psychiatry, Olomouc, Czech Republic
K. Vrbova
Affiliation:
University Hospital Olomouc, Department of Psychiatry, Olomouc, Czech Republic
K. Latalova
Affiliation:
University Hospital Olomouc, Department of Psychiatry, Olomouc, Czech Republic
M. Slepecky
Affiliation:
Faculty of Social Science and Health Care, Constantine the Philosopher University in Nitra, Department of Psychology Sciences, Nitra, Slovak Republic
M. Zatkova
Affiliation:
Faculty of Social Science and Health Care, Constantine the Philosopher University in Nitra, Department of Psychology Sciences, Nitra, Slovak Republic
A. Kotianova
Affiliation:
Faculty of Social Science and Health Care, Constantine the Philosopher University in Nitra, Department of Psychology Sciences, Nitra, Slovak Republic

Abstract

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Objective

The goal of this study was to examine the influence of dissociation, hope, personality trait and selected demographic factors in treatment response of this group of patients.

Methods

Pharmacoresistant depressive inpatients completed clinical global impression – both objective and subjective form, Beck depression inventory, and Beck anxiety inventory at baseline and after six weeks of combined pharmacotherapy and psychotherapy (group cognitive behavioral or group psychodynamic). The Internalized Stigma Of Mental Illness Scale, Dissociative Experience Scale Adult Dispositional Hope Scale, and temperament and character inventory were completed at the start of the treatment with the intention to find predictors of treatment efficacy.

Results

The study included 72 patients hospitalized for the pharmacoresistant major depression, 63 of them finished the study. The mean scores of BDI-II, BAI, subjCGI, and objCGI significantly decreased during the treatment. BDI-II relative change statistically significantly correlated with the total ISMI score, discrimination experience (ISMI subscale), and harm avoidance (TCI-R personality trait). According to stepwise regression, the strongest factors connected to BDI-II relative change were the duration of the disorder and discrimination experience (ISMI). ObjCGI relative change significantly correlated with the level of dissociation, the total ISMI score, and hope in ADHS total score, and self-directedness. According to stepwise regression, the strongest factor connected to objCGI relative change was discrimination experience (ISMI).

Conclusions

According to our results, the patients with pharmacoresistant depressive disorders, who have had more experience with discrimination because of their mental struggles, showed a poorer response to treatment.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-poster walk: Consultation liaison psychiatry and psychosomatics–Part 1
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. s244
Copyright
Copyright © European Psychiatric Association 2017
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