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Transcranial Magnetic Stimulation for Borderline Personality Disorder: Rationale, Stimulation Site and Methods

Published online by Cambridge University Press:  16 April 2020

L. Cailhol ,
E. Bui ,
B. Roussignol ,
A.-H. Moncany ,
R. Klein ,
M. Simonetta-Moreau ,
C. Thalamas ,
P. Birmes  and
L. Schmitt
L. Cailhol
Affiliation:
Centre d'Investigation Clinique, Centre Hospitalier Universitaire Purpan, Toulouse, France
E. Bui
Affiliation:
Service de Psychiatrie et de Psychologie Médicale, Toulouse, France
B. Roussignol
Affiliation:
Laboratoire du Stress Traumatique, Centre Hospitalo, Universitaire Purpan, Toulouse, France
A.-H. Moncany
Affiliation:
Laboratoire du Stress Traumatique, Centre Hospitalo, Universitaire Purpan, Toulouse, France
R. Klein
Affiliation:
Secteur G08, Centre Hospitalier Spécialisé Gérard Marchant, Toulouse, France
M. Simonetta-Moreau
Affiliation:
Service de Neurologie, Centre Hospitalo, Universitaire Purpan, Toulouse, France
C. Thalamas
Affiliation:
Centre d'Investigation Clinique, Centre Hospitalier Universitaire Purpan, Toulouse, France
P. Birmes
Affiliation:
Laboratoire du Stress Traumatique, Centre Hospitalo, Universitaire Purpan, Toulouse, France
L. Schmitt
Affiliation:
Service de Psychiatrie et de Psychologie Médicale, Toulouse, France

Abstract

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Borderline personality disorder (BPD) is characterized by pervasive instability in moods, interpersonal relationships, self-image, and behavior. This disorder is associated with a significant rate of suicide attempts and completed suicides (4 to 10%), a major impairment in social functioning and an increased healthcare utilization cost. Treatments available include psychotherapy and pharmacotherapy. Research has shown some efficacy of repetitive Transcranial Magnetic Stimulation (rTMS) on post-traumatic stress disorder and mood disorder which both share common biological or clinical features with BPD. It is then likely that rTMS might prove efficient on BPD symptoms.

A review of the literature on neuroimaging and neuropsychology of BPD shows a hypoactivity of the dorsolateral prefrontal cortex which may be a potential target site for rTMS.

We will conduct a pilot randomized sham-controlled trial on 30 BPD patients assessing the efficacy of a 10-day course of daily rTMS on neuropsychological tasks, BPD symptoms severity, risk taking behaviour, depression and general psychopathology.

Type
P02-78
Information
European Psychiatry , Volume 24 , Issue S1: 17th EPA Congress - Lisbon, Portugal, January 2009, Abstract book , January 2009 , 24-E768
Copyright
Copyright © European Psychiatric Association 2009
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