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Unconventional side effects of antidepressants: Focus on emotional blunting

Published online by Cambridge University Press:  23 March 2020

V. Falaschi ,
S. Baroni ,
F. Mucci ,
H. Akiskal  and
D. Marazziti
V. Falaschi
Affiliation:
Università di Pisa, Dipartimento di Medicina Clinica e Sperimentale, Pisa, Italy
S. Baroni
Affiliation:
Università di Pisa, Dipartimento di Medicina Clinica e Sperimentale, Pisa, Italy
F. Mucci
Affiliation:
Università di Pisa, Dipartimento di Medicina Clinica e Sperimentale, Pisa, Italy
H. Akiskal
Affiliation:
University of California, Department of Psychiatry, San Diego, USA
D. Marazziti
Affiliation:
Università di Pisa, Dipartimento di Medicina Clinica e Sperimentale, Pisa, Italy

Abstract

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Objectives

The aim of this study was to investigate the unconventional side-effects of selective serotonin reuptake inhibitors (SSRIs) and tricyclics (TCAs) antidepressants during long-term treatment of depression, with a special focus on emotional blunting and, in particular, on the possible changes of some features of loving relationships.

Methods

Two hundred outpatients (130 women and 70 men, mean age ± SD: 43.4 ± 11.1 years) were enrolled. They were suffering from mild or moderate depression, according to DSM–5 criteria, treated with one antidepressant for at least six months and involved in a long-term loving relationship. A specifically designed test, the so-called “sex, attachment, love” (SALT) questionnaire was built to assess the possible changes of the loving relationship.

Results

The results showed differences between the two genders, in particular women taking TCAs reported more sexual side effects than men, whereas men taking SSRIs complained a reduction of the feelings of love and attachment towards the partner.

Conclusions

Antidepressants seem to have a dimorphic effect on some elements of loving relationships, however these results need to be further explored.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-Poster Viewing: Psychopharmacology and pharmacoeconomics
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S751
Copyright
Copyright © European Psychiatric Association 2017
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