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Vers un élargissement des indications des antidépresseurs

Published online by Cambridge University Press:  16 April 2020

H Allain ,
C Benéton  and
E Bellissant
H Allain
Affiliation:
Laboratoire de pharmacologie, faculté de médecine, avenue du Professeur-Léon-Bernard, 35043Rennes Cedex, France
C Benéton
Affiliation:
Laboratoire de pharmacologie, faculté de médecine, avenue du Professeur-Léon-Bernard, 35043Rennes Cedex, France
E Bellissant
Affiliation:
Laboratoire de pharmacologie, faculté de médecine, avenue du Professeur-Léon-Bernard, 35043Rennes Cedex, France
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Résumé

Les données neurochimiques directes ou indirectes obtenues dans différentes affections du système nerveux central (SNC) constituent la base rationnelle de I'utilisation des médicaments dans des indications précises. Les antidépresseurs (AD) tricycliques agissant sur les principales amines du SNC trouvent ainsi des applications thérapeutiques variées en dehors de la dépression. L'arrivée de nouveaux AD au mécanisme d'action, soit plus cibé (la sérotonine), soit différent (IMAO) pose de nouveau cette question des indications psychiatriques et neurologiques, qui ne peut être résolue que par des essais méthodologiquement irréprochables. Une telle approche évitera d'ignorer pendant des années des effets thérapeutiques incontestables d'une molécule ancienne, tel que ce fut le cas de la clomipramine dans les troubles obsessifs-compulsifs.

Keywords

antidépresseursdépressionsérotonineindications thérapeutiques
Type
Research Article
Information
European Psychiatry , Volume 9 , Issue S2: Psychiatrie: quelles convergences pour quelle insertion? , 1994 , pp. 25 - 29
Copyright
Copyright © Elsevier, Paris 1994

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