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What are the reciprocal influences of randomized clinical trials and the patient–psychiatrist relationship?

Published online by Cambridge University Press:  16 April 2020

J. Catteau ,
C. Cyran ,
R. Bordet ,
C.E. Thomas  and
B.A. Dupuis
J. Catteau
Affiliation:
REPP (Réseau d'Expérimentation en Psycho-Pharmacologie), Service de Pharmacologie, CHRU de Lille, 2 avenue Oscar-Lambret, 59045Lille cedex, France
C. Cyran
Affiliation:
REPP (Réseau d'Expérimentation en Psycho-Pharmacologie), Service de Pharmacologie, CHRU de Lille, 2 avenue Oscar-Lambret, 59045Lille cedex, France
R. Bordet
Affiliation:
REPP (Réseau d'Expérimentation en Psycho-Pharmacologie), Service de Pharmacologie, CHRU de Lille, 2 avenue Oscar-Lambret, 59045Lille cedex, France
C.E. Thomas
Affiliation:
REPP (Réseau d'Expérimentation en Psycho-Pharmacologie), Service de Pharmacologie, CHRU de Lille, 2 avenue Oscar-Lambret, 59045Lille cedex, France
B.A. Dupuis
Affiliation:
REPP (Réseau d'Expérimentation en Psycho-Pharmacologie), Service de Pharmacologie, CHRU de Lille, 2 avenue Oscar-Lambret, 59045Lille cedex, France
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Summary

The goal of this prospective investigation was to study the course and the quality of patient-psychiatrist relationships during phase II / phase III clinical trials of antidepressant medication prescribed for depressive disorders. All patients who participated in the clinical trials (and subsequently in this survey) signed written informed consent statements and were subject to random double blind treatment assignment. Retrospective analysis of 118 investigations was carried out, and the patients involved were questioned concerning their experiences and impressions during and after the study. Data show that the outcome of clinical trials of antidepressant drugs are not a function of pre-existing good patient-psychiatrist relationships. On the other hand, no effects on the patient-psychiatrist relationship were found as a result of the experimental procedure, and it can be concluded that no detrimental effects on future patient-psychiatrist relationships were incurred.

Keywords

antidepressantclinical trialpatient—psychiatrist relationship
Type
Original articles
Information
European Psychiatry , Volume 14 , Issue 2 , April 1999 , pp. 93 - 100
Copyright
Copyright © Elsevier, Paris 1999

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