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3-Methyl-4-Chlorophenol for Prion Decontamination of Medical Devices

Published online by Cambridge University Press:  21 June 2016

Constanze Riemer ,
Theresa Bamme ,
Simon Wing Fai Mok  and
Michael Baier
Constanze Riemer
Affiliation:
Robert-Koch-Institut, Nordufer, Germany
Theresa Bamme
Affiliation:
Robert-Koch-Institut, Nordufer, Germany
Simon Wing Fai Mok
Affiliation:
Robert-Koch-Institut, Nordufer, Germany
Michael Baier*
Affiliation:
Robert-Koch-Institut, Nordufer, Germany
*
Project “Neurodegenerative Diseases”, Robert-Koch-Institut, Nordufer 20, 13353 Berlin, Germany (baierm@rki.de)
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Abstract

Disinfectants containing 3-methyl-4-chlorophenol were tested for their capacity to inactivate the infectious agent of scrapie. Coincubation of brain homogenates prepared from terminally ill scrapie-infected hamsters with the disinfectants rendered the prion protein PrPSc sensitive to proteinase K digestion. Inoculation of hamsters with disinfectant-treated samples indicated a reduction in infectivity levels to below the limit of detection.

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 27 , Issue 7 , July 2006 , pp. 778 - 780
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2006

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