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An Efficacy Evaluation of a Synergized Glutaraldehyde-Phenate Solution in Disinfecting Respiratory Therapy Equipment Contaminated During Patient Use

Published online by Cambridge University Press:  02 January 2015

Timothy R. Townsend ,
Siok-Bi Wee  and
Beryl Koblin
Timothy R. Townsend*
Affiliation:
Hospital Epidemiology Unit, The Johns Hopkins Hospital and the Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland
Siok-Bi Wee
Affiliation:
Hospital Epidemiology Unit, The Johns Hopkins Hospital and the Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland
Beryl Koblin
Affiliation:
Hospital Epidemiology Unit, The Johns Hopkins Hospital and the Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland
*
Administration 229, The Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21205
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Abstract

Reusable, corrugated, expiratory limb ventilator tubing that had been in use for 24 hours, were randomly allocated to one of three groups: no treatment (N=36); detergent wash (N = 83); or a detergent wash followed by a 10 minute immersion in a 1:16 dilution of synergized glutaraldehyde-phenate solution which was reused for 30 days. (Between 10 and 22 tubes were tested in each five day interval during this 30-day period.) Tubes were quantitatively and qualitatively cultured. There were significant differences in both the percent of contaminated tubes (no treatment = 92%, detergent wash = 72%, glutaraldehyde-phenate = 0 to 20%) and numbers of microorganisms per tube (no treatment = 3.2 × 106, detergent wash = 1.3 x 104, glutaraldehyde-phenate = 0 to 182) between groups. There was no apparent decrease in glutaraldehyde-phenate's efficacy throughout the 30-day reuse period, and in the final five days of the reuse period it was completely effective.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 3 , Issue 3 , June 1982 , pp. 240 - 246
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1982

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References

1. Reinarz, JA, et al. The potential role of inhalation therapy equipment in nosocomial pulmonary infection. J Clin Invest 1965;44:831–839.CrossRefGoogle ScholarPubMed
2. Joseph, JM. Disease transmission by inefficiently sanitized anesthetizing apparatus. JAMA 1952;149:1196–1198.CrossRefGoogle ScholarPubMed
3. Buxton, AE, et al. Nosocomial respiratory tract infection and colonization with Acinetobacter calcoaceticus . Am J Med 1978;65:507–513.Google Scholar
4. Sanford, JP, Pierce, AK. Lower respiratory tract infections. In: Hospital Infections. Bennett, JV, Brackman, PS, eds. Boston: Little, Brown and Co., 1979, pp. 255–286.Google Scholar
5. Gorman, SP, Scott, EM, Russell, AD. A review: Antimicrobial activity, uses and mechanisms of action of glularaldehyde. J Appl Bacteriol 1980;48:161–190.CrossRefGoogle Scholar
6. Use-dilution method(2)—Official final action. In: Official Methods of Analysis of the Association of Official Analytical Chemists, 13th ed. Horwitz, W, ed. Washington, DC: Association of Official Analytical Chemists, 1980, pp. 58-59.Google Scholar
7. McPherson, K. Statistics: The problem of examining accumulating data more than once. N Engl J Med 1974;290:501–502.CrossRefGoogle ScholarPubMed
8. Simmons, BP. Guidelines for hospital environmental control. Infection Control 1981:2:131–146.CrossRefGoogle Scholar
9. Leach, ED. A new synergized glutaraldehyde-phenate sterilizing solution and concentrated disinfectant. Infection Control 1981;2:26–30.Google Scholar
10. Manual for Clinical Microbiology. 3rd ed. Washington, DC: American Society for Microbiology, 1980.Google Scholar