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Emergence of High-Level Mupirocin Resistance in Methicillin-Resistant Staphylococcus aureus Isolated From Brazilian University Hospitals

Published online by Cambridge University Press:  02 January 2015

Kátia Regina Netto dos Santos ,
Leila de Souza Fonseca  and
Paulo Pinto Gontijo Filho
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Abstract

Surveillance for methicillin-resistant Staphylococcus aureus (MRSA) was implemented in Rio de Janeiro and Uberlândia University Hospitals, which had different policies on use of mupirocin. One hundred fourteen multiresistant MRSA strains were isolated from 62 patients. Mupirocin resistance was observed in 63% of strains in Rio de Janeiro, where there was extensive use of topical mupirocin, and 6.1% in Uberlândia, where its use was rare.

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 17 , Issue 12 , December 1996 , pp. 813 - 816
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1996

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References

1. Wey, SB. Infection control in a country with annual inflation of 3,600°%. Infect Control Hosp Epidemiol 1995;16:175–178.CrossRefGoogle Scholar
2. Pannuti, CS, Grimbaum, RS. An overview of nosocomial infection control in Brazil. Infect Control Hosp Epidemiol 1995;16:170–174.CrossRefGoogle ScholarPubMed
3. Pereira, MCG, Hanna, G, Richtmann, K, Kusakano, EJV, Shamatai, Y, Mendonça, JS. Perfil atual de sensibilidade de bactérias aos antimicrobianos usuais: anâlise de 1841 amostras de secreçôes, sangue, urina e liquor. Presented at the 24th Congresso da Sociedade Brasileira de Medicina Tropical; February 28-March 3, 1988; Manaus, Brazil. Abstract 102.Google Scholar
4. Lofti, CJ, Silva, JE, Machado, AMO, et al. Comparaçâo da suscepti-bilidade aos antimicrobianos das bactérias isoladas de infecçôes hospitalares entre os anos de 1986-1987 no Hospital Säo Paulo. Presented at the 24th Congresso da Sociedade Brasileira de Medicina Tropical; February 28-March 3, 1988; Manaus, Brazil. Abstract 105.Google Scholar
5. Hudson, IRB. The efficacy of intranasal mupirocin in the prevention of staphylococcal infections: a review of recent experience. J Hosp Infect 1994;27:81–98.CrossRefGoogle ScholarPubMed
6. Udo, EE, Pearman, JR, Grubb, WB. Emergence of high-level mupirocin resistance in methicillin-resistant Staphylococcus aureus in western Australia. J Hosp Infect 1994;26:157–165.CrossRefGoogle ScholarPubMed
7. Layton, MC, Perez, M, Heald, P, Patterson, JE. An outbreak of mupirocin-resistant Staphylococcus aureus on a dermatology ward associated with an environmental reservoir. Infect Control Hosp Epidemiol 1993;14:369–375.CrossRefGoogle ScholarPubMed
8. Smith, MD, Sanghrajka, M, Lock, S. Mupirocin-resistant Staphylococcus aureus . Lancet 1987;2:1472–1473.Google Scholar
9. Cookson, BD, Lacey, RW, Noble, WC, Reeves, DS, Wise, R, Redhead, RJ. Mupirocin-resistant Staphylococcus aureus . Lancet 1990;335:1095–1096.CrossRefGoogle ScholarPubMed
10. National Committee for Clinical Laboratory Standards. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically. 3rd ed. Villanova, PA: NCCLS; 1993. Approved standard:M7–A3.Google Scholar
11. National Committee for Clinical Laboratory Standards. Performance Standards for Antimicrobial Disk Susceptibility Tests. 5th ed. Villanova, PA: NCCLS; 1993. Approved stan-dard:M2–A5.Google Scholar
12. Fuchs, PC, Jones, RN, Barry, AL. Interpretative criteria for disk diffusion susceptibility testing of mupirocin, a topical antibiotic. J Clin Microbiol 1990;28:608–609.CrossRefGoogle Scholar
13. Bradley, SF, Ramsey, MA, Morton, TM, Kauffman, CA. Mupirocin resistance: clinical and molecular epidemiology. Infect Control Hosp Epidemiol 1995;16:354–358.CrossRefGoogle ScholarPubMed
14. Casewell, MW, Hill, RLR. In vitro activity of mupirocin (‘pseudomonic acid') against clinical isolates of Staphylococcus aureus . J Antimicrob Chemother 1985;15:523–531.CrossRefGoogle ScholarPubMed
15. Farr, BM. Rifamycins, . In: Mandell, GL, Bennett, JE, Dolin, R, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 4th ed. New York, NY: Churchill Livingstone; 1995:317–329.Google Scholar