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Lack of Benefit With Combination Therapy for Clostridium difficile Infection

Published online by Cambridge University Press:  06 February 2017

Jessica C. Njoku ,
Trevor C. Van Schooneveld ,
Mark E. Rupp ,
Keith M. Olsen ,
Fang Qiu ,
Jane L. Meza  and
Elizabeth D. Hermsen
Jessica C. Njoku*
Affiliation:
Nebraska Medicine, Omaha, Nebraska Department of Pharmacy Practice, University of Nebraska Medical Center, Omaha, Nebraska
Trevor C. Van Schooneveld
Affiliation:
Nebraska Medicine, Omaha, Nebraska Department of Internal Medicine, Section of Infectious Diseases, University of Nebraska Medical Center, Omaha, Nebraska
Mark E. Rupp
Affiliation:
Nebraska Medicine, Omaha, Nebraska Department of Internal Medicine, Section of Infectious Diseases, University of Nebraska Medical Center, Omaha, Nebraska
Keith M. Olsen
Affiliation:
Nebraska Medicine, Omaha, Nebraska Department of Pharmacy Practice, University of Nebraska Medical Center, Omaha, Nebraska
Fang Qiu
Affiliation:
Department of Biostatistics, University of Nebraska Medical Center, Omaha, Nebraska
Jane L. Meza
Affiliation:
Department of Biostatistics, University of Nebraska Medical Center, Omaha, Nebraska
Elizabeth D. Hermsen
Affiliation:
Department of Pharmacy Practice, University of Nebraska Medical Center, Omaha, Nebraska Department of Global Population Health, Merck & Co., Inc., Kenilworth, New Jersey.
*
Address correspondence to Jessica C. Njoku, PharmD, Good Shepherd Medical Center, 700 E Marshall Ave, Longview, TX 75601 (chikajcn@gmail.com).
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Abstract

Limited data exist regarding combination therapy for Clostridium difficile infection (CDI). After adjusting for confounders in a cohort of patients with CDI and≥1 year old, combination therapy was not associated with significant differences in clinical outcomes, but it was associated with prolonged duration of therapy (1.22 days; 95% confidence interval, 1.03–1.44 days; P=.02).

Infect Control Hosp Epidemiol 2017;38:602–605

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 38 , Issue 5 , May 2017 , pp. 602 - 605
Copyright
© 2017 by The Society for Healthcare Epidemiology of America. All rights reserved 

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References

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