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Progress and Challenges in Implementing the Research on ESKAPE Pathogens

Published online by Cambridge University Press:  02 January 2015

Louis B. Rice
Louis B. Rice*
Affiliation:
Medical Service, Louis Stokes Cleveland VA Medical Center, and the Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio
*
Medical Service 111(W), Louis Stokes Cleveland VA Medical Center, 10701 East Boulevard, Cleveland, OH 44106 (Louis.rice@va.gov)
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Abstract

The ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) are responsible for a substantial percentage of nosocomial infections in the modern hospital and represent the vast majority of isolates whose resistance to antimicrobial agents presents serious therapeutic dilemmas for physicians. Over the years, improved molecular biology techniques have led to detailed information about individual resistance mechanisms in all these pathogens. However, there remains a lack of compelling data on the interplay between resistance mechanisms and between the bacteria themselves. In addition, data on the impact of clinical interventions to decrease the prevalence of resistance are also lacking. The difficulty in identifying novel antimicrobial agents with reliable activity against these pathogens argues for an augmentation of research in the basic and population science of resistance, as well as careful studies to identify optimal strategies for infection control and antimicrobial use.

Type
Supplement Article
Information
Infection Control & Hospital Epidemiology , Volume 31 , Issue S1: Papers from the Fifth Decennial International Conference on Healthcare-Associated Infections , November 2010 , pp. S7 - S10
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2010

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