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Transmission of Clostridioides difficile infection (CDI) from patients less than 3 years of age in a pediatric oncology setting

Published online by Cambridge University Press:  03 January 2020

Elizabeth Robilotti*
Affiliation:
Infectious Diseases, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York Infection Control, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York
Weihua Huang
Affiliation:
Department of Pathology, New York Medical College, Valhalla, New York
N. Esther Babady
Affiliation:
Infectious Diseases, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York Clinical Microbiology Service, Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York
Donald Chen
Affiliation:
Infection Prevention and Control Department, Westchester Medical Center, Valhalla, New York Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, NY, USA
Mini Kamboj
Affiliation:
Infectious Diseases, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York Infection Control, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York
*
Author for correspondence: Elizabeth Robilotti, Email: robilotti@gmail.com

Abstract

Clostridioides difficile infection (CDI) is prevalent in pediatric oncology patients, but the transmission risk to peers is unknown. In 224 children with CDI, multilocus sequence typing (MLST) identified only 7 alleged transmission events (18%) originating from children <3 years old. None of these events were corroborated by WGS.

Type
Concise Communication
Copyright
© 2020 by The Society for Healthcare Epidemiology of America. All rights reserved.

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References

Sammons, JS, Gerber, JS, Tamma, PD, et al.Diagnosis and management of Clostridium difficile infection by pediatric infectious diseases physicians. J Pediatr Infect Dis Soc 2014;3:4348.CrossRefGoogle ScholarPubMed
Kociolek, LK, Espinosa, RO, Gerding, DN, et al.Natural Clostridioides difficile toxin immunization in colonized infants. Clin Infect Dis 2019. doi: 10.1093/cid/ciz582.CrossRefGoogle ScholarPubMed
Pechal, A, Lin, K, Allen, S, Reveles, K.National age group trends in Clostridium difficile infection incidence and health outcomes in United States community hospitals. BMC Infect Dis 2016;16:682.10.1186/s12879-016-2027-8CrossRefGoogle ScholarPubMed
2016 Annual report for the emerging infections program for Clostridium difficile infection. Centers for Disease Control and Prevention website. https://www.cdc.gov/hai/eip/Annual-CDI-Report-2016.html. Published 2016. Accessed March 1, 2019.Google Scholar
Rousseau, C, Lemee, L, Le Monnier, A, Poilane, I, Pons, JL, Collignon, A.Prevalence and diversity of Clostridium difficile strains in infants. J Med Microbiol 2011;60:11121118.CrossRefGoogle ScholarPubMed
Al Ghounaim, M, Longtin, Y, Gonzales, M, Merckx, J, Winters, N, Quach, C.Clostridium difficile infections in children: impact of the diagnostic method on infection rates. Infect Control Hosp Epidemiol 2016;37:10871093.CrossRefGoogle Scholar
McDonald, LC, Gerding, DN, Johnson, S, et al.Clinical practice guidelines for Clostridium difficile infection in adults and children: 2017 update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). Clin Infect Dis 2018;66:987994.CrossRefGoogle Scholar
Sherertz, RJ, Sarubbi, FA.The prevalence of Clostridium difficile and toxin in a nursery population: a comparison between patients with necrotizing enterocolitis and an asymptomatic group. J Pediatr 1982;100:435439.CrossRefGoogle Scholar
Vendetti, N, Zaoutis, T, Coffin, SE, Sammons, JS.Risk factors for in-hospital mortality among a cohort of children with Clostridium difficile infection. Infect Control Hosp Epidemiol 2015;36:11831189.CrossRefGoogle ScholarPubMed
Griffiths, D, Fawley, W, Kachrimanidou, M, et al.Multilocus sequence typing of Clostridium difficile. J Clin Microbiol 2010;48:770778.CrossRefGoogle ScholarPubMed
McDonald, LC, Gerding, DN, Johnson, S, et al.Clinical practice guidelines for Clostridium difficile infection in adults and children: 2017 update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). Clin Infect Dis 2018;66:e1e48.CrossRefGoogle Scholar
Kociolek, LK, Gerding, DN, Espinosa, RO, Patel, SJ, Shulman, ST, Ozer, EA.Clostridium difficile whole-genome sequencing reveals limited transmission among symptomatic children: a single-center analysis. Clin Infect Dis 2018;67:229234.CrossRefGoogle ScholarPubMed
Castagnola, E, Battaglia, T, Bandettini, R, et al.Clostridium difficile–associated disease in children with solid tumors. Support Care Cancer 2009;17:321324.10.1007/s00520-008-0507-0CrossRefGoogle ScholarPubMed
Spigaglia, P, Barbanti, F, Castagnola, E, Diana, MC, Pescetto, L, Bandettini, R.Clostridium difficile causing pediatric infections: new findings from a hospital-based study in Italy. Anaerobe 2017;48:262268.CrossRefGoogle ScholarPubMed
de Blank, P, Zaoutis, T, Fisher, B, Troxel, A, Kim, J, Aplenc, R.Trends in Clostridium difficile infection and risk factors for hospital acquisition of Clostridium difficile among children with cancer. J Pediatr 2013;163:699705.CrossRefGoogle ScholarPubMed
Pai, S, Aliyu, SH, Enoch, DA, Karas, JA.Five years experience of Clostridium difficile infection in children at a UK tertiary hospital: proposed criteria for diagnosis and management. PLoS One 2012;7:e51728.CrossRefGoogle Scholar
Eyre, DW, Cule, ML, Griffiths, D, et al.Detection of mixed infection from bacterial whole-genome sequence data allow assessment of its role in Clostridium difficile transmission. PLoS Comput Biol 2013;9:e1003059.CrossRefGoogle Scholar
van den Berg, RJ, Ameen, HA, Furusawa, T, Claas, EC, van der Vorm, ER, Kuijper, EJ.Coexistence of multiple PCR-ribotype strains of Clostridium difficile in faecal samples limits epidemiological studies. J Med Microbiol 2005;54:173179.10.1099/jmm.0.45825-0CrossRefGoogle ScholarPubMed
Isaac, S, Scher, JU, Djukovic, A, et al.Short- and long-term effects of oral vancomycin on the human intestinal microbiota. J Antimicrob Chemother 2017;72:128136.CrossRefGoogle Scholar
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