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Comparison of fundamental physical properties of the model cells (protocells) and the living cells reveals the need in protophysiology

Published online by Cambridge University Press:  08 January 2016

V.V. Matveev Open the ORCID record for V.V. Matveev [Opens in a new window]
V.V. Matveev*
Affiliation:
Laboratory of Cell Physiology, Institute of Cytology, Russian Academy of Sciences, Tikhoretsky Ave 4, St. Petersburg 194064, Russia
*
e-mail: vladimir.matveev@gmail.com
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Abstract

A hypothesis is proposed about potassium ponds being the cradles of life enriches the gamut of ideas about the possible conditions of pre-biological evolution on the primeval Earth, but does not bring us closer to solving the real problem of the origin of life. The gist of the matter lies in the mechanism of making a delimitation between two environments – the intracellular environment and the habitat of protocells. Since the sodium–potassium pump (Na+/K+-ATPase) was discovered, no molecular model has been proposed for a predecessor of the modern sodium pump. This has brought into life the idea of the potassium pond, wherein protocells would not need a sodium pump. However, current notions of the operation of living cells come into conflict with even physical laws when trying to use them to explain the origin and functioning of protocells. Thus, habitual explanations of the physical properties of living cells have become inapplicable to explain the corresponding properties of Sidney Fox's microspheres. Likewise, existing approaches to solving the problem of the origin of life do not see the need for the comparative study of living cells and cell models, assemblies of biological and artificial small molecules and macromolecules under physical conditions conducive to the origin of life. The time has come to conduct comprehensive research into the fundamental physical properties of protocells and create a new discipline – protocell physiology or protophysiology – which should bring us much closer to solving the problem of the origin of life.

Keywords

action potentialHodgkin–Huxley modelmicrospheresphysiologyproteinoidsprotocellprotophysiology
Type
Review Article
Information
International Journal of Astrobiology , Volume 16 , Issue 1 , January 2017 , pp. 97 - 104
Copyright
Copyright © Cambridge University Press 2016 

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References

Adams, R.L. & Wente, S.R. (2013). Uncovering nuclear pore complexity with innovation. Cell 152(6), 1218–1221.CrossRefGoogle ScholarPubMed
Aumiller, W.M. Jr., Davis, B.W. & Keating, C.D. (2013). Phase separation as a possible means of nuclear compartmentalization. Int. Rev. Cell Mol. Biol. 307, 109–149.Google Scholar
Brangwynne, C.P. (2013). Phase transitions and size scaling of membrane-less organelles. J. Cell Biol. 203(6), 875–881.Google Scholar
Chang, D.C. (1977). A physical model of nerve axon – I. Ionic distribution, potential profile, and resting potential. Bull. Math. Biol. 39(1), 1–22.Google Scholar
Chang, D.C. (1978). A physical model of nerve axon. II: action potential and excitation currents. Voltage-clamp studies of chemical driving forces of Na+ and K+ in squid giant axon. Physiol. Chem. Phys. 11(3), 263–288.Google Scholar
Chen, C.S., Chung, W.J., Hsu, I.C., Wu, C.M. & Chin, W.C. (2012). Force field measurements within the exclusion zone of water. J. Biol. Phys 38(1), 113–120.Google Scholar
Damadian, R. (1973). Biological ion exchanger resins. Ann. NY Acad. Sci. 204(1), 211–248.CrossRefGoogle ScholarPubMed
Dubina, M.V., Vyazmin, S.Y., Boitsov, V.M., Nikolaev, E.N., Popov, I.A., Kononikhin, A.S., Eliseev, I.E. & Natochin, Y.V. (2013). Potassium ions are more effective than sodium ions in salt induced peptide formation. Orig. Life Evol. Biosph. 43(2), 109–117.Google Scholar
Fox, S.W. (1965). Simulated natural experiments in spontaneous organization of morphological units from protenoid. In The Origins of Prebiological Systems and their Molecular Matrices, ed. Fox, , S.W., pp. 336–382. Academic Press, New York.Google Scholar
Fox, S.W. (1992). Thermal proteins in the first life and in the ‘mind-body’ problem. In Evolution of Information Processing Systems, ed. Haefner, K., pp. 203–228. Springer–Verlag, Berlin, Heidelberg.Google Scholar
Hodgkin, A.L. & Huxley, A.F. (1952). A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol. 117(4), 500–544.CrossRefGoogle ScholarPubMed
Hyman, A.A. & Brangwynne, C.P. (2011). Beyond stereospecificity: liquids and mesoscale organization of cytoplasm. Dev. Cell 21(1), 14–16.Google Scholar
Hyman, A.A., Weber, C.A. & Jülicher, F. (2014). Liquid-liquid phase separation in biology. Annu. Rev. Cell Dev. Biol. 30, 39–58.Google Scholar
Ishima, Y., Przybylski, A.T. & Fox, S.W. (1981). Electrical membrane phenomena in spherules from proteinoid and lecithin. BioSystems 13(4), 243–251.CrossRefGoogle ScholarPubMed
Jockusch, R.A., Lemoff, A.S. & Williams, E.R. (2001). Effect of metal ion and water coordination on the structure of a gas-phase amino acid. J. Am. Chem. Soc. 123(49), 12255–12265.Google Scholar
Karreman, G. (1973). Towards a physical understanding of physiological excitation as a cooperative specific adsorption phenomenon. Bull. Math. Biol. 35(1–2), 149–171.Google Scholar
Karreman, G. (1977). Cooperative specific adsorption phenomena in biology. Bull. Math. Biol. 39(2), 267–273.CrossRefGoogle ScholarPubMed
Kodandaramaiah, S.B., Franzesi, G.T., Chow, B.Y., Boyden, E.S. & Forest, C.R. (2012). Automated whole-cell patch-clamp electrophysiology of neurons in vivo. Nat. Methods 9(6), 585–587.Google Scholar
Li, P., Banjade, S., Cheng, H.C., Kim, S., Chen, B., Guo, L., Llaguno, M., Hollingsworth, J.V., King, D.S., Banani, S.F., Russo, P.S., Jiang, Q.X., Nixon, B.T. & Rosen, M.K. (2012). Phase transitions in the assembly of multivalent signalling proteins. Nature 483(7389), 336–340.Google Scholar
Matveev, V.V. (2005). Protoreaction of protoplasm. Cell. Mol. Biol. 51(8), 715–723.Google ScholarPubMed
Matveev, V.V. (2010). Native aggregation as a cause of origin of temporary cellular structures needed for all forms of cellular activity, signaling and transformations. Theor. Biol. Med. Model. 7, 19–20.Google Scholar
Mulkidjanian, A.Y. & Galperin, M.Y. (2007). Physico-chemical and evolutionary constraints for the formation and selection of first biopolymers: towards the consensus paradigm of the abiogenic origin of life. Chem. Biodivers. 4(9), 2003–2015.Google Scholar
Mulkidjanian, A.Y., Bychkov, A.Y., Dibrova, D.V., Galperin, M.Y. & Koonin, E.V. (2012). Origin of first cells at terrestrial, anoxic geothermal fields. Proc. Natl. Acad. Sci. USA 109(14), E821–E830.Google Scholar
Natochin, Y.V. (2007). The physiological evolution of animals: sodium is the clue to resolving contradictions. Herald Russ., Acad. Sci. 77(6), 581–591.Google Scholar
Oparin, A.I. (1924). Proiskhozdenie Zhizny. Izd Moskovskii Rabochii, Moscow.Google Scholar
Pinti, D.L. (2005). The origin and evolution of the oceans. In Lectures in Astrobiology, ed. Gargaud, M., Barbier, B., Martin, H. & Reisse, J., pp. 83–111. Springer–Verlag, Berlin.Google Scholar
Przybylski, A.T. (1984). Physical background of excitability: synthetic membranes and excitable cells. In Molecular Evolution and Protobiology, ed. Matsuno, K., Dose, K., Harada, K. & Rohlfing, D.L., pp. 253–266. Plenum Press, New York.Google Scholar
Rajaraman, H.S., Babu, G.N., Chavan, S.J., Achar, K.K. & Babu, P.R. (2013). Signature of potassium enrichment in granite of the Chitrial area, Nalgonda district, Andhra Pradesh: inferences using its U, Th, K2O, Na2O, Rb, Ba and Sr contents. J. Geol. Soc. India 82(1), 53–58.Google Scholar
Schidlowski, M. (2001). Carbon isotopes as biogeochemical recorders of life over 3.8 Ga of earth history: evolution of a concept. Precambr. Res. 106(1), 117–134.Google Scholar
Stratten, W.P. (1984). Protocell action potentials: a new perspective of bio-excitation. In Molecular Evolution and Protobiology, ed. Matsuno, K., Dose, K., Harada, , K. & Rohlfing, D.L. pp. 233–251. Plenum Press, New York.Google Scholar
Sulbarán, B., Toriz, G., Allan, G.G., Pollack, G.H. & Delgado, E. (2014). The dynamic development of exclusion zones on cellulosic surfaces. Cellulose 21(3), 1143–1148.Google Scholar
Switek, B. (2012). Debate bubbles over the origin of life. Nature (online issue, http://www.nature.com/news/debate-bubbles-over-the-origin-of-life-1.10024)CrossRefGoogle Scholar
Troshin, A.S. (1966). Problems of Cell Permeability. Pergamon Press, Oxford.Google Scholar
Whitney, J.A. (1988). The origin of granite: the role and source of water in the evolution of granitic magmas. Geol. Soc. Am. Bull. 100(12), 1886–1897.Google Scholar
Zhang, S.B., Zheng, Y.F., Wu, Y.B., Zhao, Z.F., Gao, S. & Wu, F.Y. (2006). Zircon U–Pb age and Hf isotope evidence for 3.8 Ga crustal remnant and episodic reworking of Archean crust in South China. Earth Planet. Sci. Lett. 252(1), 56–71.Google Scholar
Zheng, J.M., Chin, W.C., Khijniak, E. & Pollack, G.H. (2006). Surfaces and interfacial water: evidence that hydrophilic surfaces have long-range impact. Adv. Colloid. Interface Sci. 127(1), 19–27.CrossRefGoogle ScholarPubMed