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Quality of economic evaluations of ventricular assist devices: A systematic review

Published online by Cambridge University Press:  18 June 2020

Sarah Fontenay ,
Lionel Catarino ,
Soumeya Snoussi ,
Hélène van den Brink ,
Judith Pineau ,
Patrice Prognon  and
Nicolas Martelli Open the ORCID record for Nicolas Martelli [Opens in a new window]
Sarah Fontenay
Affiliation:
Pharmacy Department, Georges Pompidou European Hospital, AP-HP, 20 Rue Leblanc, 75015Paris, France
Lionel Catarino
Affiliation:
Pharmacy Department, Georges Pompidou European Hospital, AP-HP, 20 Rue Leblanc, 75015Paris, France
Soumeya Snoussi
Affiliation:
Pharmacy Department, Georges Pompidou European Hospital, AP-HP, 20 Rue Leblanc, 75015Paris, France
Hélène van den Brink
Affiliation:
Université Paris-Saclay GRADES, 92290Châtenay-Malabry, France
Judith Pineau
Affiliation:
Pharmacy Department, Georges Pompidou European Hospital, AP-HP, 20 Rue Leblanc, 75015Paris, France
Patrice Prognon
Affiliation:
Pharmacy Department, Georges Pompidou European Hospital, AP-HP, 20 Rue Leblanc, 75015Paris, France
Nicolas Martelli*
Affiliation:
Pharmacy Department, Georges Pompidou European Hospital, AP-HP, 20 Rue Leblanc, 75015Paris, France Université Paris-Saclay GRADES, 92290Châtenay-Malabry, France
*
Author for correspondence: Nicolas Martelli, E-mail: nicolas.martelli@egp.aphp.fr
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Abstract

Objective

Because of a lack of suitable heart donors, alternatives to transplantation are required. These alternatives can have high costs. The aim of this study was to perform a systematic review of cost-effectiveness studies of ventricular assist devices (VADs) and to assess the level of evidence of relevant studies. The purpose was not to present economic findings.

Methods

A systematic review was performed using four electronic databases to identify health economic evaluation studies dealing with VADs. The methodological quality and reporting quality of the studies was assessed using three different tools, the Drummond, Cooper, and CHEERS (Consolidated Health Economic Evaluation Reporting Standards) checklists.

Results

Of the 1,258 publications identified, thirteen articles were included in this review. Twelve studies were cost–utility analyses and one was a cost-effectiveness analysis. According to the Cooper hierarchy scale, the quality of the data used was heterogeneous. The level of evidence used for clinical effect sizes, safety data, and baseline clinical data was of poor quality. In contrast, cost data were of high quality in most studies. Quality of reporting varied between studies, with an average score of 17.4 (range 15–19) according to the CHEERS checklist.

Conclusion

The current study shows that the quality of clinical data used in economic evaluations of VADs is rather poor in general. This is a concern that deserves greater attention in the process of health technology assessment of medical devices.

Keywords

Economic evaluationMedical deviceVentricular assist deviceSystematic review
Type
Assessment
Information
International Journal of Technology Assessment in Health Care , Volume 36 , Issue 4 , August 2020 , pp. 380 - 387
Copyright
Copyright © The Author(s), 2020. Published by Cambridge University Press

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