Hostname: page-component-cd9895bd7-lnqnp Total loading time: 0 Render date: 2024-12-27T23:15:42.935Z Has data issue: false hasContentIssue false
  • English
  • Français

The validity of amnestic MCI and non-amnestic MCI at age 75 in the prediction of Alzheimer's dementia and vascular dementia

Published online by Cambridge University Press:  03 February 2012

S. Jungwirth ,
S. Zehetmayer ,
M. Hinterberger ,
K. H. Tragl  and
P. Fischer
S. Jungwirth*
Affiliation:
Ludwig Boltzmann Institute of Aging Research, Vienna, Austria
S. Zehetmayer
Affiliation:
Section for Medical Statistics, Medical University of Vienna, Vienna, Austria
M. Hinterberger
Affiliation:
Ludwig Boltzmann Institute of Aging Research, Vienna, Austria
K. H. Tragl
Affiliation:
Ludwig Boltzmann Institute of Aging Research, Vienna, Austria
P. Fischer
Affiliation:
Ludwig Boltzmann Institute of Aging Research, Vienna, Austria Department of Psychiatry, Medical Research Society Vienna DC, Danube Hospital, Vienna, Austria
*
Correspondence should be addressed to: S. Jungwirth, PhD, Ludwig Boltzmann Institute of Aging Research, Langobardenstraße 122, 1220 Vienna, Austria. Phone: + 43 1 28802 4209; Fax: + 43 1 28802 4281. Email: susanne.jungwirth@wienkav.at.
Get access

Abstract

Background: Clinical subtypes of mild cognitive impairment (MCI) were assigned as potential prodromes to various types of dementia. Amnestic MCI (aMCI) is said to have a high likelihood of progressing to Alzheimer's dementia (AD) and non-amnestic MCI (naMCI) subtypes are assumed to have a higher likelihood of progressing to non-AD dementia. The aim of this study was to investigate the prognostic accuracy of aMCI and naMCI for the development of AD, vascular dementia (VaD), and mixed dementia.

Methods: In this longitudinal study, 487 subjects without dementia (cognitively healthy: n = 387; MCI cases: n = 115) aged 75 years at baseline, who participated in a population-based cohort study (Vienna Transdanube Aging study), were available for analysis. The observation period was 90 months. The diagnoses of the clinical MCI subtypes were made according to common criteria. The outcome (AD, VaD, mixed dementia) was described for both MCI subtypes. Diagnostic values of aMCI and naMCI according to incident AD, VaD, and mixed dementia were determined.

Results: AD was the most common type of dementia following both MCI subtypes. Participants with aMCI were more likely to progress to AD than participants with naMCI. The proportion of incident VaD and mixed dementia did not differ concerning the MCI subtypes. The positive predictive value for both MCI subtypes was low (range: 1%–46%), whereas the negative predictive value was high (range: 86%–99%).

Conclusions: The increased risk of clinical MCI subtypes for a particular type of dementia could only be confirmed for aMCI and incident AD.

Keywords

mild cognitive impairmentprognostic accuracydiagnostic valuespopulation-based study
Type
Research Article
Information
International Psychogeriatrics , Volume 24 , Issue 6 , June 2012 , pp. 959 - 966
Copyright
Copyright © International Psychogeriatric Association 2012

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Berres, M., Monsch, A. U., Bernasconi, F., Thalmann, B. and Stähelin, H. B. (2000). Normal ranges of neuropsychological tests for the diagnosis of Alzheimer's disease. Studies in Health Technology and Informatics, 77, 195–199.Google ScholarPubMed
Blackford, R. C. and La Rue, A. (1989). Criteria for diagnosing age-associated memory impairment: proposed improvements from the field. Developmental Neuropsychology, 5, 295–306.CrossRefGoogle Scholar
Busse, A., Hensel, A., Gühne, U., Angermeyer, M. C. and Riedel-Heller, S. G. (2006). Mild cognitive impairment: long-term course of four clinical subtypes. Neurology, 67, 2176–2185.CrossRefGoogle ScholarPubMed
Dlugaj, M. et al. (2010). Prevalence of mild cognitive impairment and its subtypes in the Heinz Nixdorf Recall study cohort. Dementia and Geriatric Cognitive Disorders, 30, 362–373.CrossRefGoogle ScholarPubMed
Ebly, E. M., Hogan, D. B. and Parhad, I. M. (1995). Cognitive impairment in the nondemented elderly: results from the Canadian study of health and aging. Archives of Neurology, 52, 612–619.CrossRefGoogle ScholarPubMed
Fischer, P. et al. (2002). Vienna-Transdanube-Aging “VITA:” study design, recruitment strategies and level of participation. Journal of Neural Transmission, 62 (Suppl.), 103–114.Google Scholar
Fischer, P. et al. (2007). Conversion from subtypes of mild cognitive impairment to Alzheimer dementia. Neurology, 68, 288–291.CrossRefGoogle ScholarPubMed
Fischer, P. et al. (2008). Risk factors for Alzheimer dementia in a community-based birth cohort at the age of 75 years. Dementia and Geriatric Cognitive Disorders, 25, 501–507.CrossRefGoogle Scholar
Hughes, C. P., Berg, L., Danziger, W. L., Coben, L. A. and Martin, R. L. (1982). A new clinical scale for the staging of dementia. British Journal of Psychiatry, 140, 566–572.CrossRefGoogle ScholarPubMed
Jagust, W. (2008). Is amnestic mild cognitive impairment always AD? Neurology, 70, 502–503.CrossRefGoogle ScholarPubMed
Jorm, A. and Jolley, D. (1998). The incidence of dementia. Neurology, 51, 728–733.CrossRefGoogle ScholarPubMed
Kral, V. A. (1962). Senescent forgetfulness: benign and malignant. Canadian Medical Association Journal, 86, 257–260.Google ScholarPubMed
Lawton, M. and Brody, E. (1969). Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist, 9, 179–186.CrossRefGoogle ScholarPubMed
Levy, R. (1994). Aging-associated cognitive decline. International Psychogeriatrics, 6, 63–68.Google ScholarPubMed
Lopez, O. L. et al. (2007). Incidence of dementia in mild cognitive impairment in the cardiovascular health study cognition study. Archives of Neurology, 64, 416–420.CrossRefGoogle ScholarPubMed
Manly, J. J., Tang, M. X., Schupf, N., Stern, Y., Vonsattel, J. P. G. and Mayeux, R. (2008). Frequency and course of mild cognitive impairment in a multiethnic community. Annals of Neurology, 63, 494–506.CrossRefGoogle Scholar
McKeith, I. G. et al. (1996). Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB International Workshop. Neurology, 47, 1113–1124.CrossRefGoogle Scholar
McKhann, G., Drachman, D., Folstein, M., Katzmann, R., Price, D. and Stadlan, E. M. (1984). Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology, 34, 939–944.CrossRefGoogle ScholarPubMed
Morris, J. C. et al. (1989). The Consortium to Establish a Registry for Alzheimer's Disease (CERAD), Part I: clinical and neuropsychological assessment of Alzheimer's disease. Neurology, 39, 1159–1165.Google Scholar
Palmer, K. et al. (2010). Neuropsychiatric predictors of progression from amnestic-mild cognitive impairment to Alzheimer's disease: the role of depression and apathy. Journal of Alzheimer's Disease, 20, 175–183.CrossRefGoogle ScholarPubMed
Petersen, R. C., Smith, G. E., Waring, S. C., Ivnik, R. J., Tangalos, E. G. and Kokmen, E. (1999). Mild cognitive impairment: clinical characterization and outcome. Archives of Neurology, 56, 303–308.CrossRefGoogle ScholarPubMed
Petersen, R. C. (2004). Mild cognitive impairment as a diagnostic entity. Journal of Internal Medicine, 256, 182–194.CrossRefGoogle ScholarPubMed
Petersen, R. C. et al. (2001). Current concepts in mild cognitive impairment. Archives of Neurology, 58, 1985–1992.CrossRefGoogle ScholarPubMed
Petersen, R. C. et al. (2010). Prevalence of mild cognitive impairment is higher in men. Neurology, 75, 889–897.CrossRefGoogle ScholarPubMed
Rasquin, S. M. C., Lodder, J., Visser, P. J., Lousberg, R. and Verhey, F. R. J. (2005). Predictive accuracy of MCI subtypes for Alzheimer's disease and vascular dementia in subjects with mild cognitive impairment. Dementia and Geriatric Cognitive Disorders, 19, 113–119.CrossRefGoogle ScholarPubMed
Reitan, R. M. (1956). Trail Making Test: Manual for Administration, Scoring, and Interpretation. Indianapolis, IN: Indiana University.Google Scholar
Román, G. C. (1993). Vascular dementia – diagnostic criteria for research studies: report of the NINDS-AIREN International Workshop. Neurology, 43, 250–260.CrossRefGoogle ScholarPubMed
Rountree, S. D., Waring, S. C., Chan, W. C., Lupo, P. J., Darby, E. J. and Doody, R. S. (2007). Importance of subtle amnestic and nonamnestic deficits in mild cognitive impairment: prognosis and conversion to dementia. Dementia and Geriatric Cognitive Disorders, 24, 476–482.CrossRefGoogle ScholarPubMed
Saß, H., Wittchen, H. U. and Zaudig, M. (1996). Diagnostisches und Statistisches Manual Psychischer Störungen DSM-IV, 1st edn.Göttingen: Hogrefe.Google Scholar
Yaffe, K., Petersen, R. C., Lindquist, K., Kramer, J. and Miller, B. (2006). Subtype of mild cognitive impairment and progression to dementia and death. Dementia and Geriatric Cognitive Disorders, 22, 312–319.CrossRefGoogle ScholarPubMed