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Clarifying dementia risk factors: treading in murky waters

Published online by Cambridge University Press:  26 May 2016

Halima Amjad  and
Esther S. Oh
Halima Amjad*
Affiliation:
Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Esther S. Oh
Affiliation:
Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
*
Email: hamjad1@jhmi.edu
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Extract

In light of the growing burden of dementia, continued research into risk factors and potential contributors to disease development is essential. Clearly established risk factors can not only inform our understanding of disease pathophysiology and treatments but also identify potential preventive strategies. While age and the ApoE4 allele have consistently been shown to increase risk of developing dementia (Kukull et al., 2002), other risk factors have been less studied or have had inconsistent findings. The study by Booker and colleagues (Booker et al., 2016) re-examines proposed late-life medical risk factors for incident dementia in a large population-based case-control study. This important contribution is best interpreted in the context of existing research.

Type
Commentary
Information
International Psychogeriatrics , Volume 28 , Issue 7 , July 2016 , pp. 1057 - 1058
Copyright
Copyright © International Psychogeriatric Association 2016 

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References

Booker, A., EC Jacob, L., Rapp, M., Bohlken, J. and Kostev, K. (2016). Risk factors for dementia diagnosis in German primary care patients. International Psychogeriatrics. doi:10.1017/S1041610215002082.Google Scholar
Fitzpatrick, A. L. et al. (2009). Midlife and late-life obesity and the risk of dementia: cardiovascular health study. Archives of Neurology, 66, 336–342.Google Scholar
Gomm, W. et al. (2016). Association of proton pump inhibitors with risk of dementia: a pharmacoepidemiological claims data analysis. JAMA Neurology, 73, 410–416. doi:10.1001/jamaneurol.2015.4791.Google Scholar
Haenisch, B. et al. (2015). Risk of dementia in elderly patients with the use of proton pump inhibitors. European Archives of Psychiatry and Clinical Neuroscience, 265, 419–428.Google Scholar
Ilomaki, J., Jokanovic, N., CK Tan, E. and Lonnroos, E. (2015). Alcohol consumption, dementia and cognitive decline: an overview of systematic reviews. Current Clinical Pharmacology, 10, 204–212.Google Scholar
Kukull, W. A. et al. (2002). Dementia and alzheimer disease incidence: a prospective cohort study. Archives of Neurology, 59, 1737–1746.CrossRefGoogle ScholarPubMed
Kuller, L. H. (2016). Do proton pump inhibitors increase the risk of dementia? JAMA Neurology, 73, 379–381. doi:10.1001/jamaneurol.2015.4931.Google Scholar
Li, G. et al. (2007). Age‐Varying association between blood pressure and risk of dementia in those aged 65 and older: a community‐based prospective cohort study. Journal of the American Geriatrics Society, 55, 1161–1167.Google Scholar
Mielke, M. M. et al. (2010). The 32-year relationship between cholesterol and dementia from midlife to late life. Neurology, 75, 1888–1895. doi:10.1212/WNL.0b013e3181feb2bf.Google Scholar
Muldoon, M. F., Ryan, C. M., Sereika, S. M., Flory, J. D. and Manuck, S. B. (2004). Randomized trial of the effects of simvastatin on cognitive functioning in hypercholesterolemic adults. The American Journal of Medicine, 117, 823–829.Google Scholar
Satizabal, C. L. et al. (2016). Incidence of dementia over three decades in the framingham heart study. New England Journal of Medicine, 374, 523–532.Google Scholar
Sink, K. M. et al. (2009). Angiotensin-converting enzyme inhibitors and cognitive decline in older adults with hypertension: results from the cardiovascular health study. Archives of Internal Medicine, 169, 1195– 1202.Google Scholar
Song, Y., Nie, H., Xu, Y., Zhang, L. and Wu, Y. (2013). Association of statin use with risk of dementia: a meta‐analysis of prospective cohort studies. Geriatrics & Gerontology International, 13, 817–824.CrossRefGoogle ScholarPubMed
Yasar, S. et al. (2013). Antihypertensive drugs decrease risk of alzheimer disease: ginkgo evaluation of memory study. Neurology, 81, 896–903. doi:10.1212/WNL.0b013e3182a35228.CrossRefGoogle ScholarPubMed