Hostname: page-component-78c5997874-94fs2 Total loading time: 0 Render date: 2024-11-11T08:05:09.719Z Has data issue: false hasContentIssue false

Do frailty and depression interact to heighten risk of death?

Published online by Cambridge University Press:  23 August 2021

David D. Ward*
Affiliation:
Geriatric Medicine Research, Centre for Health Care of the Elderly, Nova Scotia Health Authority, Halifax, Nova Scotia, Canada Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
Ravi Bhat
Affiliation:
Department of Rural Health, University of Melbourne, Shepparton, Victoria, Australia
*

Abstract

Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Commentary
Copyright
© International Psychogeriatric Association 2021

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Abizanda Soler, P. et al. (2011). Frailty and dependence in Albacete (FRADEA study): reasoning, design and methodology. Revista Espanola De Geriatria Y Gerontologia, 46, 8188. doi: 10.1016/j.regg.2010.10.004 CrossRefGoogle ScholarPubMed
Chang, H.-Y. et al. (2019). The co-occurrence of frailty (accumulation of functional deficits) and depressive symptoms, and its effect on mortality in older adults: a longitudinal study. Clinical Interventions in Aging 14, 16711680. doi: 10.2147/CIA.S210072 CrossRefGoogle ScholarPubMed
Charlson, M. E., Pompei, P., Ales, K. L. and MacKenzie, C. R. (1987). A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. Journal of Chronic Diseases 40, 373383. doi: 10.1016/0021-9681(87)90171-8 CrossRefGoogle ScholarPubMed
Collard, R.M. et al. (2015). Frailty as a predictor of the incidence and course of depressed mood. Journal of the American Medical Directors Association 16, 509514. doi: 10.1016/j.jamda.2015.01.088 CrossRefGoogle ScholarPubMed
Fried, L.P. et al. (2001). Frailty in older adults: evidence for a phenotype. The Journals of Gerontology: Series A 56, M146M157. doi: 10.1093/gerona/56.3.M146 CrossRefGoogle ScholarPubMed
Ledberg, A. (2020). Exponential increase in mortality with age is a generic property of a simple model system of damage accumulation and death. PLoS One 15, e0233384. doi: 10.1371/journal.pone.0233384 CrossRefGoogle ScholarPubMed
Li, H. et al (2018). Time-dependent depressive symptoms and risk of cardiovascular and all-cause mortality among the Chinese elderly: The Beijing Longitudinal Study of Aging. Journal of Cardiology 72, 356362. doi: 10.1016/j.jjcc.2018.02.015 CrossRefGoogle ScholarPubMed
Mitnitski, A. B., Mogilner, A. J. and Rockwood, K. (2001). Accumulation of deficits as a proxy measure of aging. TheScientificWorld 1, 323336. doi: 10.1100/tsw.2001.58 CrossRefGoogle ScholarPubMed
Penninx, B. W., Geerlings, S. W., Deeg, D. J., van Eijk, J. T., van Tilburg, W. and Beekman, A. T. (1999). Minor and major depression and the risk of death in older persons. Archives of General Psychiatry 56, 889895. doi: 10.1001/archpsyc.56.10.889 CrossRefGoogle ScholarPubMed
Rockwood, K. and Howlett, S. E. (2019). Age-related deficit accumulation and the diseases of ageing. Mechanisms of Ageing and Development 180, 107116. doi: 10.1016/j.mad.2019.04.005 CrossRefGoogle ScholarPubMed
Ruiz-Grao, M., Sanchez-Jurado, P., Molina-Alarcon, M., Hernandez-Martinez, A., Avendano-Cespedes, A. and Abizanda Soler, P. (2020). Frailty, depression risk and 10-year mortality in older adults: the FRADEA Study. International Psychogeriatrics, 33, 803812. doi: 10.1017/S1041610220003506 Google Scholar
Shin, C. et al. (2019). Usefulness of the 15-item geriatric depression scale (GDS-15) for classifying minor and major depressive disorders among community-dwelling elders. Journal of Affective Disorders 259, 370375. doi: 10.1016/j.jad.2019.08.053 CrossRefGoogle ScholarPubMed
Soysal, P. et al. (2017). Relationship between depression and frailty in older adults: a systematic review and meta-analysis. Ageing Research Reviews 36, 7887. doi: 10.1016/j.arr.2017.03.005 CrossRefGoogle ScholarPubMed
Theou, O., Brothers, T. D., Mitnitski, A. and Rockwood, K. (2013). Operationalization of frailty using eight commonly used scales and comparison of their ability to predict all-cause mortality. Journal of the American Geriatrics Society 61, 15371551. doi: 10.1111/jgs.12420 CrossRefGoogle ScholarPubMed
Tsiampalis, T. and Panagiotakos, D. B. (2020). Missing-data analysis: socio-demographic, clinical and lifestyle determinants of low response rate on self-reported psychological and nutrition related multi-item instruments in the context of the ATTICA epidemiological study. BMC Medical Research Methodology 20, 148. doi: 10.1186/s12874-020-01038-3 CrossRefGoogle ScholarPubMed
Wallace, L. M. K., Theou, O., Godin, J., Andrew, M. K., Bennett, D.A. and Rockwood, K. (2019). Investigation of frailty as a moderator of the relationship between neuropathology and dementia in Alzheimer’s disease: a cross-sectional analysis of data from the Rush Memory and Aging Project. The Lancet Neurology 18, 177184. doi: 10.1016/S1474-4422(18)30371-5 CrossRefGoogle ScholarPubMed
Ward, D. D., Wallace, L. M. K. and Rockwood, K. (2020). Cumulative health deficits, APOE genotype, and risk for later-life mild cognitive impairment and dementia. Journal of Neurology, Neurosurgery, and Psychiatry, Published Online First: 13th November 2020. doi: 10.1136/jnnp-2020-324081 Google ScholarPubMed
White, J. et al. (2016). Duration of depressive symptoms and mortality risk: the English Longitudinal Study of Ageing (ELSA). The British Journal of Psychiatry 208, 337342. doi: 10.1192/bjp.bp.114.155333 CrossRefGoogle Scholar
Yesavage, J.A. et al. (1982). Development and validation of a geriatric depression screening scale: a preliminary report. Journal of Psychiatric Research 17, 3749. doi: 10.1016/0022-3956(82)90033-4 CrossRefGoogle ScholarPubMed