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The GAB2 and BDNF polymorphisms and the risk for late-onset Alzheimer's disease in an elderly Brazilian sample

Published online by Cambridge University Press:  08 April 2015

Renalice Neves Vieira ,
Joalce Dornelas Magalhães ,
Jemima Sant’Anna ,
Mateus Massao Moriguti ,
Débora Marques de Miranda ,
Luiz De Marco ,
Edgar Nunes de Moraes ,
Marco Aurélio Romano-Silva ,
Maria Aparecida Camargos Bicalho  and
Jonas Jardim de Paula
...Show all authors
Renalice Neves Vieira*
Affiliation:
INCT de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100Brazil
Joalce Dornelas Magalhães
Affiliation:
Department of Internal Medicine, Universidade Federal de Minas Gerais, Belo Horizonte 30130-100, Brazil
Jemima Sant’Anna
Affiliation:
Department of Internal Medicine, Universidade Federal de Minas Gerais, Belo Horizonte 30130-100, Brazil
Mateus Massao Moriguti
Affiliation:
Academy Medical, Universidade Federal de Minas Gerais, Belo Horizonte 30130-100, Brazil
Débora Marques de Miranda
Affiliation:
INCT de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100Brazil Department of Pediatrics, Universidade Federal de Minas Gerais, Belo Horizonte 30130-100, Brazil
Luiz De Marco
Affiliation:
INCT de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100Brazil Department of Surgery, Universidade Federal de Minas Gerais, Belo Horizonte 30130-100, Brazil
Edgar Nunes de Moraes
Affiliation:
INCT de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100Brazil Department of Internal Medicine, Universidade Federal de Minas Gerais, Belo Horizonte 30130-100, Brazil
Marco Aurélio Romano-Silva
Affiliation:
INCT de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100Brazil Department of Mental Health, Universidade Federal de Minas Gerais, Belo Horizonte 30130-100, Brazil
Maria Aparecida Camargos Bicalho
Affiliation:
INCT de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100Brazil Department of Internal Medicine, Universidade Federal de Minas Gerais, Belo Horizonte 30130-100, Brazil
Jonas Jardim de Paula
Affiliation:
INCT de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100Brazil
Marco Túlio Gualberto Cintra
Affiliation:
Department of Internal Medicine, Universidade Federal de Minas Gerais, Belo Horizonte 30130-100, Brazil
*
Correspondence should be addressed to: Renalice Neves Vieira, INCT de Medicina Molecular, Av. Professor Alfredo Balena, 190, Santa Efigênia, 30.130-100, Belo Horizonte, Minas Gerais, Brasil. Phone: +55 31 8854-5208. Email: renalicevieira@gmail.com.
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Abstract

Background:

Evidences suggest that GAB2 and BDNF genes may be associated with Alzheimer's disease (AD). We aimed to investigate the GAB2 rs2373115 and BDNF rs6265 polymorphisms and the risk of AD in a Brazilian sample.

Methods:

269 AD patients and 114 controls were genotyped with Real-time PCR. Multifactor dimensionality reduction (MDR) was employed to explore the effects of gene–gene interactions.

Results:

GAB2 and BDNF were not associated with AD in our sample. Nevertheless BDNF Val allele (rs6265) presented a synergic association with the APOE ε4 allele. A multiple logistic regression demonstrated that the APOE ε4 allele and years of education were the best predictors for AD. In ε4 non-carriers sex, education and hypertension were independently correlated with AD, while in ε4 carriers we did not observe any association. The findings were further confirmed by bootstrapping method.

Conclusions:

Our data suggest that the interaction of BDNF and APOE has significant effect on AD. Moreover in absence of ε4, female sex, low level of education and hypertension are independently associated with AD. Interventions aimed to prevent AD should focus on these factors and also taking into account the APOE alleles.

Keywords

Alzheimer’s diseaseGAB2BDNFAPOErisk factors
Type
Research Article
Information
International Psychogeriatrics , Volume 27 , Special Issue 10: Psychosocial and Ethical Aspects of Dementia , October 2015 , pp. 1687 - 1692
Copyright
Copyright © International Psychogeriatric Association 2015 

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