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Neuropathology of Vascular Cognitive Impairment and Vascular Dementia

Published online by Cambridge University Press:  10 January 2005

Paul G. Ince
Affiliation:
Neuropathology, Academic Unit of Pathology, Division of Genomic Medicine, University of Sheffield Medical School, Sheffield, UK
Malee S. Fernando
Affiliation:
Neuropathology, Academic Unit of Pathology, Division of Genomic Medicine, University of Sheffield Medical School, Sheffield, UK

Abstract

Understanding of vascular substrates of cognitive decline in the elderly is evoloving to include a major emphasis on the impact of small vessel disease (SVD). While existing concepts of multi-infarct dementia and strategic infarct dementia remain valid, they present difficulty in generalizing clinicopathological correlations from patient to patient. The range and significance of lesions that should be included as manifestations of SVD are unresolved, as is their impact on, and association with, neurodegenerative changes. This mini-review summarizes the authors' views on SVD substrates leading to cognitive decline and proposes priorities for pathological investigations of human cerebrovascular mechanisms leading to cognitive decline.

Type
PATHOPHYSIOLOGY
Copyright
© 2003 International Psychogeriatric Association

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