Hostname: page-component-cd9895bd7-dzt6s Total loading time: 0 Render date: 2024-12-27T08:22:03.470Z Has data issue: false hasContentIssue false
  • English
  • Français

Slow Progression of White-Matter Changes

Published online by Cambridge University Press:  10 January 2005

Reinhold Schmidt ,
Helena Schmidt ,
Peter Kapeller  and
Franz Fazekas
Reinhold Schmidt
Affiliation:
Department of Neurology, Karl-Franzens University, Graz, Austria MR Center, Karl-Franzens University, Graz, Austria
Helena Schmidt
Affiliation:
Institute of Medical Biochemistry and Medical Molecular Biology, Karl-Franzens University, Graz, Austria
Peter Kapeller
Affiliation:
Department of Neurology, Karl-Franzens University, Graz, Austria MR Center, Karl-Franzens University, Graz, Austria
Franz Fazekas
Affiliation:
Department of Neurology, Karl-Franzens University, Graz, Austria MR Center, Karl-Franzens University, Graz, Austria
Get access

Abstract

A three-year follow-up of 273 participants (mean age 60 years) of the Austrian Stroke Prevention Study provides the first information on the rate, clinical predictors, and cognitive consequences of MRI white-matter lesions in elderly individuals without neuropsychiatric disease. Lesion progression was found in 17.9% of individuals over a time period of 3 years. Diastolic blood pressure and early confluent or confluent white-matter hyperintensities at baseline were the only significant predictors of white-matter hyperintensity progression. Lesion progression had no influence on the course of neuropsychologic test performance over the observational period, but the statistical power of this analysis was low.

Keywords

White-matter lesionsrisk factorscerebral small-vessel diseasecognition
Type
SECONDARY PREVENTION (CVD BRAIN AT RISK OF COGNITIVE DECLINE)
Information
International Psychogeriatrics , Volume 15 , Issue S1 , July 2003 , pp. 173 - 176
Copyright
© 2003 International Psychogeriatric Association

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)