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Pulmonary embolism secondary to clozapine therapy

Published online by Cambridge University Press:  13 June 2014

Anwar ul-Haq  and
Edmond Holland
Anwar ul-Haq*
Affiliation:
Causeway Hospital, Coleraine, Northern Ireland
Edmond Holland
Affiliation:
St Fintan's Hospital, Portlaoise, Co Laois, Ireland
*
*Correspondence E-mail: dranwarulhaq@hotmail.com
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Abstract

Clozapine is an atypical antipsychotic indicated for paranoid schizophrenia (treatment resistant type). However its use has been limited by the well established association with neutropenia and agranulocytosis. It has also been suggested that clozapine therapy is associated with other serious adverse effects such as fatal myocarditis or cardiomyopathy.

Keywords

ClozapinePulmonary embolism
Type
Case Reports
Information
Irish Journal of Psychological Medicine , Volume 26 , Issue 3 , September 2009 , pp. 149 - 150
Copyright
Copyright © Cambridge University Press 2009

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References

1.Hyers, TM. Venous thromboembolism. Am J Respir Crit Care Med. 1999 Jan;159(1):1–14.CrossRefGoogle ScholarPubMed
2.Goldhaber, SZ. Pulmonary embolism. N Engl J Med 1998; 339:93.CrossRefGoogle ScholarPubMed
3.Value of the ventilation/perfusion scan in acute pulmonary embolism. Results of the prospective investigation of pulmonary emobolism diagnosis (PIOPED). The PIOPED Investigators. JAMA 1990; 263:2753.CrossRefGoogle Scholar
4.Walker, AM, Lanza, LL, Arellano, F, Rothman, KJ. Mortality in current and former users of Clozapine. Epidemiology 1997;8:671–7.CrossRefGoogle ScholarPubMed
5.Pan, R, John, V, Hagg, S. Clozapine and pulmonary embolism. Acta Psychiatr Scand. 2003 Jul; 108(1):76–7.Google ScholarPubMed
6.Hagg, S, Spigset, O. Antipsychotic-induced venous thromboembolism: a review of the evidence. CNS Drugs 2002;16(11):765–76.Google ScholarPubMed
7.Coodin, S, Ballegeer, T. Clozapine therapy and pulmonary embolism. Can J Psychiatry 2000;45(5):395.Google ScholarPubMed
8.Suttman, I, Dittert, S, Landgraf, Ret al.Clozapine and Sudden Death. Lancet 2000:355:842–3.CrossRefGoogle Scholar