Hostname: page-component-78c5997874-ndw9j Total loading time: 0 Render date: 2024-11-11T05:51:49.805Z Has data issue: false hasContentIssue false
  • English
  • Français

The use of clozapine in an individual with moderate intellectual disability, aggressive behaviour and resistant psychosis

Published online by Cambridge University Press:  13 June 2014

Manzar Kamal  and
Mary Kelly
Manzar Kamal
Affiliation:
St. Mary's, Drumcar, Co Louth, Ireland
Mary Kelly
Affiliation:
St. Mary's, Drumcar, Co Louth, Ireland
Get access Rights & Permissions [Opens in a new window]

Abstract

The case of a 32 year old man with moderate intellectual disability, severe behavioural problems and psychotic symptoms is described. Having tried various traditional antipsychotics he was commenced on clozapine with a marked improvement in symptoms. Clozapine is a useful drug for the treatment of schizophrenia in the intellectually disabled who are refractory to the conventional antipsychotics. It improves aggressive and self-injurious behaviour which may be in addition to its antipsychotic effect.

Keywords

Moderate intellectual disabilityTreatment resistant psychosisClozapine
Type
Case Reports
Information
Irish Journal of Psychological Medicine , Volume 16 , Issue 1 , March 1999 , pp. 32 - 33
Copyright
Copyright © Cambridge University Press 1999

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Sovner, R. Is it behaviour or mental illness?Paper presented to PBA Consultants. Pittsburgh: 1991 October.Google Scholar
2.Vynke, J. The treatment of behaviour disorders in idiocy and imbecility with clozapine. Pharmacopsychiatry 1974; 7: 225–9.CrossRefGoogle Scholar
3.Cohen, SA, Underwood, MT. The use of clozapine in a mentally retarded and aggressive population. J Clin Psychiatry 1994; 55: 440–4.Google Scholar
4.Sajatovic, Met al.The use of clozapine in borderline intellectual functioning and mentally retarded schizophrenic patients. Compr Psychiatry 1994; 35: 29–33.CrossRefGoogle ScholarPubMed
5.Pary, RJ. Clozapine in three individuals with mild mental retardation and treatment refractory psychiatric disorders. Ment Retard 1994; 32: 323–7.Google ScholarPubMed
6.Boachie, A, McGinnity, M. Use of clozapine in a mental hospital – report of the first 17 patients. Ir J Psych Med 1997; 14(1): 16–9.CrossRefGoogle Scholar
7.Breese, GRet al.Behavioural differences between neonatal and six adult hydroxydopamine treated rats to dopamine agonists: relevance to neurological symptoms in clinical syndromes with reduced brain dopamine. J Pharmacol Exp Ther 1984a; 231: 343–54.Google Scholar
8.Breese, GRet al.Pharmacological evaluation of SCH-12679: Evidence of an in vivo antagonism of Dl dopamine receptors. J Pharmacol Exp Ther 1990; 252: 558–76.Google Scholar