Hostname: page-component-cd9895bd7-dk4vv Total loading time: 0 Render date: 2024-12-26T06:06:09.433Z Has data issue: false hasContentIssue false

Bipolar affective disorder as the initial manifestation of multiple sclerosis

Published online by Cambridge University Press:  13 June 2014

Adarsh Vohra*
Affiliation:
Parkwood, East Park Drive, Blackpool FY3 8PW Lancashire, United Kingdom
Caroline Leeming
Affiliation:
Parkwood, East Park Drive, Blackpool FY3 8PW, Lancashire, United Kingdom
*
*Correspondence Email: akvohra1950@yahoo.com

Abstract

The association between bipolar affective disorder and multiple sclerosis continues to be poorly understood in view of the limited knowledge and research in this field. Here we present the case of a 43 year old female with bipolar affective disorder who later developed multiple sclerosis. The relationship between the two disorders is discussed in the light of relevant and pertinent literature. It is hypothesised that bipolar affective disorder may be the presenting manifestation of multiple sclerosis and should be considered as a differential diagnosis in patients of bipolar affective disorder with neurological symptoms.

Type
Case Report
Copyright
Copyright © Cambridge University Press 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Feinstin, A. Multiple sclerosis, disease modifying treatments and depression. Mult Scler 2000; 6: 342–8.Google Scholar
2.Belmaker, RH. Bipolar disorder. N Engl J Med 2004; 351; 476–86.CrossRefGoogle ScholarPubMed
3.Edwards, LJ, Constantinescu, CS. A perspective study of conditions associated with multiple sclerosis in a cohort of 658 consecutive outpatients attending a multiple sclerosis clinic. Mult Scler 2004; 10: 575–81.CrossRefGoogle Scholar
4.Schiffer, REt, Wineman, NM, Weitkamp, LR. Association between bipolar affective disorder and multiple sclerosis. Am J Psychiatry 1986; 143: 94–5.Google ScholarPubMed
5.Garland, EJ, Zis, AP. Multiple sclerosis and affective disorders. Can J Psychiatry 1991; 36: 112–7.CrossRefGoogle ScholarPubMed
6.Peselow, ED, Deutch, SI, Fieve, RR. Coexistent manic symptoms and multiple sclerosis. Psychosomatics 1981; 22: 824–5.CrossRefGoogle ScholarPubMed
7.Kellner, CH, Davenport, Y, Post, RM. Rapidly cycling bipolar disorder and multiple sclerosis. Am J Psychiatry 1984; 141:112–3.Google ScholarPubMed
8.El Moutawakil, B, Sibal, M, Bourezgui, Met al.Manic-depressive psychosis as prevalent manifestation of multiple sclerosis. Rev Neurol (Paris) 2008; 164(5): 472–6.CrossRefGoogle ScholarPubMed
9.Hutchinson, M, Starck, J, Buckley, P. Bipolar affective disorder prior to the onset of multiple sclerosis. Acta Neurol Scand 1993; 88: 388–93.CrossRefGoogle Scholar
10.Ashgar Ali, A, Taber, KH, Hurley, RA, Hayman, LA. Pure neuropsychiatric presentation of multiple sclerosis. Am J Psychiatry 2004; 161: 226–31.CrossRefGoogle Scholar
11.Salloway, S, Price, LH, Charney, DS. Multiple sclerosis presenting as major depression: a diagnosis suggested by MRI scans but not CT Scan. J Clin Psychiatry 1988; 49: 364–6.Google Scholar
12.Becker, H. Psychotic symptoms as the initial manifestation of multiple sclerosis. Psychiatr Prax 1997; 24(2): 6972.Google ScholarPubMed