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Comparison of Multiple Measures of ADHD Symptomatology: A Multivariate Genetic Analysis

Published online by Cambridge University Press:  04 June 2001

Teresa S. Nadder ,
Judy L. Silberg ,
Michael Rutter ,
Hermine H. Maes  and
Lindon J. Eaves
Teresa S. Nadder
Affiliation:
Virginia Commonwealth University, Richmond, U.S.A.
Judy L. Silberg
Affiliation:
Virginia Commonwealth University, Richmond, U.S.A.
Michael Rutter
Affiliation:
Social, Genetic and Developmental Psychiatry Research Centre, London, U.K.
Hermine H. Maes
Affiliation:
Virginia Commonwealth University, Richmond, U.S.A.
Lindon J. Eaves
Affiliation:
Virginia Commonwealth University, Richmond, U.S.A.
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Abstract

The phenotypic and genetic interrelationships underlying ADHD symptomatology assessed by various instruments were examined on a sample of 735 male and 819 female same-sex twin pairs, aged 8 to 16 years, participating in the first phase of the Virginia Twin Study of Adolescent Behavioral Development (VTSABD). Multivariate analyses were applied to parental and teacher ratings from an investigator-based interview, the CAPA, and three questionnaires (the CBCL and the Rutter Parent and Teacher Scales). Results from patterns of intercorrelations and factor analyses of maternal measures suggested that at the phenotypic level, these assessed the same underlying behavioural construct, which differed from other emotional and behavioural constructs. However, genetic analyses showed that in addition to a common factor underlying the expression of ADHD as assessed across the range of measures, additional genetic factors were identified that were method- and rater-specific. The findings suggest that although the investigator-based interview and the behavioural checklists tap similar aspects of ADHD behaviour, there is additional rater-specific variance.

Keywords

ADD/ADHDchild behaviourgeneticsmultivariate analysisstructural equation modellingtwins
Type
Paper
Information
The Journal of Child Psychology and Psychiatry and Allied Disciplines , Volume 42 , Issue 4 , May 2001 , pp. 475 - 486
Copyright
© 2001 Association for Child Psychology and Psychiatry

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