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Breast cancer and sphingolipid signalling

Published online by Cambridge University Press:  14 July 2005

Paola Signorelli  and
Riccardo Ghidoni
Paola Signorelli
Affiliation:
Laboratory of Biochemistry and Molecular Biology, San Paolo University Hospital, School of Medicine, University of Milan, 20142 Milan, Italy
Riccardo Ghidoni
Affiliation:
Laboratory of Biochemistry and Molecular Biology, San Paolo University Hospital, School of Medicine, University of Milan, 20142 Milan, Italy
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Abstract

Cancer develops from overlapping events that tend to deregulate the metabolism and unbalance the homeostasis of cells. Sphingolipids, major components of biological membranes, are also mediators of intracellular signalling. Their metabolism can be influenced by diverse stimuli and the accumulation or deficiency of intermediates may trigger proliferation and/or impair the ability of damaged cells to undergo apoptosis. Many sphingolipid-regulated functions are implicated in tumour initiation, promotion, progression and responsiveness to chemotherapy. In this review, evidence of the alteration of sphingolipids metabolism and signalling will be discussed in breast cancer prevention and therapy.

Keywords

Ceramidesphingosinecancer
Type
Research Article
Information
Journal of Dairy Research , Volume 72 , Issue S1 , August 2005 , pp. 5 - 13
Copyright
Proprietors of Journal of Dairy Research 2005

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