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Efficacy of Panax ginseng extract combined with cephalexin as a dry cow therapy

Published online by Cambridge University Press:  18 March 2021

Camila Beccaria ,
Celina Baravalle ,
Paula Silvestrini ,
María S. Renna ,
Ana I. Molineri ,
Marcelo L. Signorini ,
Verónica E. Neder ,
Guillermo A. Suarez Archilla ,
Luis F. Calvinho  and
Bibiana E. Dallard
Camila Beccaria
Affiliation:
Laboratorio de Biología Celular y Molecular Aplicada, Instituto de Ciencias Veterinarias del Litoral (ICIVET-Litoral), Universidad Nacional del Litoral (UNL)/Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Esperanza, Santa Fe, Argentina Facultad de Ciencias Veterinarias (UNL), Esperanza, Santa Fe, Argentina
Celina Baravalle
Affiliation:
Laboratorio de Biología Celular y Molecular Aplicada, Instituto de Ciencias Veterinarias del Litoral (ICIVET-Litoral), Universidad Nacional del Litoral (UNL)/Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Esperanza, Santa Fe, Argentina Facultad de Ciencias Veterinarias (UNL), Esperanza, Santa Fe, Argentina
Paula Silvestrini
Affiliation:
Laboratorio de Biología Celular y Molecular Aplicada, Instituto de Ciencias Veterinarias del Litoral (ICIVET-Litoral), Universidad Nacional del Litoral (UNL)/Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Esperanza, Santa Fe, Argentina Facultad de Ciencias Veterinarias (UNL), Esperanza, Santa Fe, Argentina
María S. Renna
Affiliation:
Laboratorio de Biología Celular y Molecular Aplicada, Instituto de Ciencias Veterinarias del Litoral (ICIVET-Litoral), Universidad Nacional del Litoral (UNL)/Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Esperanza, Santa Fe, Argentina Facultad de Ciencias Veterinarias (UNL), Esperanza, Santa Fe, Argentina
Ana I. Molineri
Affiliation:
Instituto de Investigación de la Cadena Láctea (IdICaL), Instituto Nacional de Tecnología Agropecuaria (INTA) – CONICET, Rafaela, Santa Fe, Argentina
Marcelo L. Signorini
Affiliation:
Facultad de Ciencias Veterinarias (UNL), Esperanza, Santa Fe, Argentina Instituto de Investigación de la Cadena Láctea (IdICaL), Instituto Nacional de Tecnología Agropecuaria (INTA) – CONICET, Rafaela, Santa Fe, Argentina
Verónica E. Neder
Affiliation:
Instituto de Investigación de la Cadena Láctea (IdICaL), Instituto Nacional de Tecnología Agropecuaria (INTA) – CONICET, Rafaela, Santa Fe, Argentina
Guillermo A. Suarez Archilla
Affiliation:
Instituto de Investigación de la Cadena Láctea (IdICaL), Instituto Nacional de Tecnología Agropecuaria (INTA) – CONICET, Rafaela, Santa Fe, Argentina
Luis F. Calvinho
Affiliation:
Facultad de Ciencias Veterinarias (UNL), Esperanza, Santa Fe, Argentina Instituto de Investigación de la Cadena Láctea (IdICaL), Instituto Nacional de Tecnología Agropecuaria (INTA) – CONICET, Rafaela, Santa Fe, Argentina
Bibiana E. Dallard*
Affiliation:
Laboratorio de Biología Celular y Molecular Aplicada, Instituto de Ciencias Veterinarias del Litoral (ICIVET-Litoral), Universidad Nacional del Litoral (UNL)/Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Esperanza, Santa Fe, Argentina Facultad de Ciencias Veterinarias (UNL), Esperanza, Santa Fe, Argentina
*
Author for correspondence: Bibiana E. Dallard, Email: bdallard@fcv.unl.edu.ar
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Abstract

Our objective was to evaluate the efficacy of intramammary administration, at drying-off, of a Panax ginseng extract (PGe) combined with cephalexin (Ceph) on the post-calving bacteriological cure rate of pre-existing intramammary infections (IMI) and on the occurrence of new IMI during the dry period. In addition, milk yield and somatic cell count (SCC) in the post-treatment lactation were evaluated. One hundred and eight late-lactation cows were randomly divided into two experimental groups and were treated at drying-off with Ceph alone or PGe combined with Ceph.Cure rates for IMI present at drying-off were similar for both treatments (OR = 0.95, 95% CI = 0.33–2.74). Cure rates for Staphylococcus aureus were lower (OR = 15.4, 95% CI = 1.66–142.52) in quarters treated with PGe + Ceph than in those treated with Ceph alone. Intramammary infusion of PGe + Ceph at drying-off had no effect on preventing new dry period IMI (OR = 0.75, 95% CI = 0.38–1.51), compared with infusion of Ceph alone. Milk production and SCC in the ensuing lactation were not affected by PGe + Ceph treatment. In conclusion, addition of PGe to dry cow therapy did not show any advantage over the use of dry cow therapy alone.

Keywords

Cephalexindry cow therapyefficacyintramammary infectionsPanax ginseng
Type
Research Article
Information
Journal of Dairy Research , Volume 88 , Issue 1 , February 2021 , pp. 64 - 68
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of Hannah Dairy Research Foundation

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Footnotes

*

These authors contributed equally to this work.

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