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A freeze-fracture study of tight junction structure in sheep mammary gland epithelium during pregnancy and lactation

Published online by Cambridge University Press:  01 June 2009

Geoffrey Morgan  and
F. B. Peter Wooding
Geoffrey Morgan
Affiliation:
Institute of Animal Physiology, Babraham, Cambridge CB2 4 AT, UK
F. B. Peter Wooding
Affiliation:
Institute of Animal Physiology, Babraham, Cambridge CB2 4 AT, UK
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Summary

Freeze fractures of the tight junctions at the apices of sheep mammary secretory cells showed that the junction at 72 d of pregnancy was significantly wider than at any later stage. The number of ridges in the junction only increased significantly between 122 and 142 d of pregnancy. The initially even distribution of intramembrane particles across the tight junction changed gradually until in the fully lactating animal there were far more particles on the lateral surface of the plasmalemma. Possible correlations between these changes, the alterations in permeability of the mammary epithelium, and the differences in hormone levels are briefly discussed.

Type
Original Articles
Information
Journal of Dairy Research , Volume 49 , Issue 1 , February 1982 , pp. 1 - 11
Copyright
Copyright © Proprietors of Journal of Dairy Research 1982

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References

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