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The association between gestational age and otitis media during childhood: a population-based cohort analysis

Published online by Cambridge University Press:  18 September 2018

Majdi Imterat Open the ORCID record for Majdi Imterat [Opens in a new window] ,
Tamar Wainstock ,
Jacob Moran-Gilad ,
Eyal Sheiner  and
Asnat Walfisch
Majdi Imterat*
Affiliation:
Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Tamar Wainstock
Affiliation:
Department of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Jacob Moran-Gilad
Affiliation:
Department of Health Systems Management, School of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Eyal Sheiner
Affiliation:
Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Asnat Walfisch
Affiliation:
Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel
*
Address for correspondence: M. Imterat, Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer Sheva 84101, Israel. E-mail: magdi_333@hotmail.com
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Abstract

Otitis media (OM) carries a tremendous global health burden and potentially severe long-term consequences. The objective of this study was to determine the impact of birth at different gestational ages on the incidence of childhood OM.

A population-based cohort analysis was conducted. All singleton deliveries occurring between 1991 and 2014 at a regional tertiary medical center were included. Gestational age on delivery was divided into six subgroups: early (<34 weeks gestation; 0 out of 7) and late (34 weeks gestation; 0 out of 7 to 36 weeks gestation; 6 out of 7) preterm, and early (37 weeks gestation; 0 out of 7 to 38 weeks gestation; 6 out of 7), full (39 weeks gestation; 0 out of 7 to 40 weeks gestation; 6 out of 7), late (41 weeks gestation; 0 out of 7 to 41 weeks gestation; 6 out of 7) and post (⩾42 weeks 0 out of 7) term deliveries. Rates of OM-related hospitalizations up to 18 years of age were assessed. Weibull parametric hazards model was used to study the association between gestational age at birth and the risk for OM-related hospitalizations while controlling for potential confounders.

During the study period, 238,622 deliveries met the inclusion criteria. OM-related hospitalizations of the offspring (n=4724) were significantly more common in the preterm (early 3.6%, late 2.4%) and early-term born children (2.2%) and decreased gradually across the full (1.9%), late (1.7%) and post (1.6%) term groups (χ2-test for trends P<0.001). In the Weibull regression model, early preterm, as well as early-term deliveries exhibited an independent association with pediatric OM (adjusted hazard ratios: 1.67 and 1.09, respectively, P<0.02).

Deliveries occurring at preterm and early term are associated with higher rates of pediatric OM-related hospitalizations, which decrease gradually as gestational age advances.

Keywords

follow-upinfectionoffspringpediatric morbiditypregnancy
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 10 , Issue 2 , April 2019 , pp. 214 - 220
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2018. 

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References

1. Todberg, T, Koch A, Andersson M, et al. Incidence of otitis media in a contemporary Danish National Birth Cohort. PLoS One. 2014; 9, e111732.Google Scholar
2. Coker TR, Chan LS, Newberry SJ, et al. Diagnosis, microbial epidemiology, and antibiotic treatment of acute otitis media in children: a systematic review. JAMA. 2010; 304, 2161–2169.Google Scholar
3. American Academy of Pediatrics Subcommittee on Management of Acute Otitis Media. Diagnosis and management of acute otitis media. Pediatrics. 2004; 113, 1451.Google Scholar
4. Faden, H, Duffy, L, Boeve, M. Otitis media: back to basics. Pediatr Infect Dis J. 1998; 17, 1105–1113.Google Scholar
5. Lieberthal AS, Carroll AE, Chonmaitree T, et al. The diagnosis and management of acute otitis media. Pediatrics. 2013; 131, e964–e999.Google Scholar
6. Fiellau-Nikolajsen, M, Lous, J. Prospective tympanometry in 3-year-old children: a study of the spontaneous course of tympanometry types in a nonselected population. Arch Otolaryngol. 1979; 105, 461–466.Google Scholar
7. Teele DW, Klein JO, Chase C, et al. Otitis media in infancy and intellectual ability, school achievement, speech, and language at age 7 years. J Infect Dis. 1990; 162, 685–694.Google Scholar
8. Uhari, M, Mäntysaari, K, Niemelä, M. Meta-analytic review of the risk factors for acute otitis media. Clin Infect Dis. 1996; 22, 1079–1083.Google Scholar
9. Kero, P, Piekkala, P. Factors affecting the occurrence of acute otitis media during the first year of life. Acta Paediatrica. 1987; 76, 618–623.Google Scholar
10. Bland, RD. Otitis media in the first six weeks of life: diagnosis, bacteriology, and management. Pediatrics. 1972; 49, 187–197.Google Scholar
11. Berman, SA, Balkany, TJ, Simmons, MA. Otitis media in the neonatal intensive care unit. Pediatrics. 1978; 62, 198–201.Google Scholar
12. Bowatte G, Tham R, Allen KJ, et al. Breastfeeding and childhood acute otitis media: a systematic review and meta‐analysis. Acta Paediatrica. 2015; 104, 85–95.Google Scholar
13. Merewood A, Brooks D, Bauchner H, et al. Maternal birthplace and breastfeeding initiation among term and preterm infants: a statewide assessment for Massachusetts. Pediatrics. 2006; 118, e1048–e1054.Google Scholar
14. Newman DE, Paamoni-Keren O, Press F, et al. Neonatal outcome in preterm deliveries between 23 and 27 weeks’ gestation with and without preterm premature rupture of membranes. Arch Gynecol Obstet. 2009; 280, 7–11.Google Scholar
15. Jacobson, L. Visual dysfunction and ocular signs associated with periventricular leukomalacia in children born preterm. Acta Ophthalmol Scand. 1999; 77, 365–366.Google Scholar
16. Bhutta AT, Cleves MA, Casey PH, et al. Cognitive and behavioral outcomes of school-aged children who were born preterm: a meta-analysis. JAMA. 2002; 288, 728–737.Google Scholar
17. Lott, JW. State of the science: neonatal bacterial infection in the early 21st century. J Perinat Neonatal Nurs. 2006; 20, 62–70.Google Scholar
18. World Health Organization. ICD-10: International Statistical Classification of Diseases and Related Health, Tenth Revision [Internet] (vol. 2), 2nd edn, 2004. WHO: Geneva. Retrieved 12 August 2013 from: http://www.who.int/classifications/icd/ICD-10_2nd_ed_volume2.pdf Google Scholar
19. Tita AT, Landon MB, Spong CY, et al. Timing of elective repeat cesarean delivery at term and neonatal outcomes. N Engl J Med. 2009; 360, 111–120.Google Scholar
20. Machado Jr, Luis C, Passini Jr, et al. Neonatal outcomes of late preterm and early term birth. Eur J Obstet Gynecol Reprod Biol. 2014; 179, 204–208.Google Scholar
21. Walfisch A, Beharier O, Wainstock T, et al. Early‐term deliveries as an independent risk factor for long‐term respiratory morbidity of the offspring. Pediatr Pulmonol. 2017; 52, 198–204.Google Scholar
22. C Clark SL, Miller DD, Belfort MA, et al. Neonatal and maternal outcomes associated with elective term delivery. Am J Obstet Gynecol. 2009; 200, 156.e1–e4.Google Scholar
23. Dietz PM, Rizzo JH, England LJ, et al. Early term delivery and health care utilization in the first year of life. J Pediatr. 2012; 161, 234–239.Google Scholar
24. Walfisch A, Wainstock T, Beharier O, et al. Early term deliveries and the risk of pediatric obstructive sleep apnoea in the offspring. Paediatr Perinat Epidemiol. 2017; 31, 149–156.Google Scholar
25. Paz Levy D, Sheiner E, Wainstock T, et al. Evidence that children born at early term (37-38 6/7 weeks) are at increased risk for diabetes and obesity-related disorders. Am J Obstet Gynecol. 2017; 217, 588e1–588e11.Google Scholar
26. Spong, CY. Defining “term” pregnancy: recommendations from the Defining “Term” Pregnancy Workgroup. JAMA. 2013; 309, 2445–2446.Google Scholar
27. Statistics TCBo [Internet]. Israel in Figures 2013 [updated 25 May 2015]. Retrieved from: http://www.cbs.gov.il/www/publications/isr_in_n15e.pdf Google Scholar
28. Gouyon JB, Vintejoux A, Sagot P, et al. Neonatal outcome associated with singleton birth at 34–41 weeks of gestation. Int J Epidemiol. 2010; 39, 769–776.Google Scholar
29. American College of Obstetricians and Gynecologists. ACOG Practice Bulletin No. 97: Fetal lung maturity. Obstet Gynecol. 2008; 112, 717.Google Scholar
30. Chonmaitree T, Revai K, Grady JJ, et al. Viral upper respiratory tract infection and otitis media complication in young children. Clin Infect Dis. 2008; 46, 815–823.Google Scholar
31. Chonmaitree T, Trujillo R, Jennings K, et al. Acute otitis media and other complications of viral respiratory infection. Pediatrics. 2016; e20153555.Google Scholar
32. US Department of Health and Human Services. The health consequences of smoking—50 years of progress: a report of the surgeon general. Atlanta, GA: US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health 2014; 17.Google Scholar
33. National Center for Chronic Disease Prevention and Health Promotion [Internet]. Centers for Disease Control and Prevention, Breastfeeding Report Card. 2013. Retrieved from: www.cdc.gov/breastfeeding/pdf/2013BreastfeedingReportCard.pdf.Google Scholar
34. Ministry of Health [Internet], State of Israel 2018. Retrieved from: https://www.health.gov.il/English/Topics/Pregnancy/Vaccination_of_infants/Pages/default.aspx Google Scholar
35. Organization for Economic Co-operation and Development, Child vaccination rates (indicator) [updated 11 November 2017]. Retrieved from: https://doi.org/10.1787/b23c7d13-en Google Scholar
36. Gerten KA, Coonrod DV, Bay RC, et al. Cesarean delivery and respiratory distress syndrome: does labor make a difference? Am J Obstet Gynecol. 2005; 193, 1061–1064.Google Scholar
37. Black M, Bhattacharya S, Philip S, et al. Planned cesarean delivery at term and adverse outcomes in childhood health. JAMA. 2015; 314, 2271–2279.Google Scholar
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