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Threshold shear stress for the transition between tumbling and tank-treading of red blood cells in shear flow: dependence on the viscosity of the suspending medium

Published online by Cambridge University Press:  06 November 2013

Thomas M. Fischer  and
Rafal Korzeniewski
Thomas M. Fischer*
Affiliation:
Department of Physiology, RWTH Aachen University, Pauwelsstr. 30, 52074 Aachen, Germany
Rafal Korzeniewski
Affiliation:
Department of Physiology, RWTH Aachen University, Pauwelsstr. 30, 52074 Aachen, Germany
*
†Email address for correspondence: thmfischer@gmail.com
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Abstract

Red blood cells are the subject of diverse studies. One branch is the observation and theoretical modelling of their behaviour in a shear flow. This work deals with the flow of single red cells suspended in solutions much more viscous than blood plasma. Below a critical shear rate (${\dot {\gamma } }_{t} $) the red cells rotate with little change of their resting shape. Above that value they become elongated and aligned in the shear field. We measured ${\dot {\gamma } }_{t} $ at viscosities (${\eta }_{0} $) ranging from 10.7 to 104 mPa s via observation along the vorticity of a Poiseuille flow in a glass capillary; ${\eta }_{0} {\dot {\gamma } }_{t} $ decreased steeply with increasing ${\eta }_{0} $ up to a value of 25 mPa s and remained constant for higher values. Present theoretical models are not in keeping with the measured data. Modifications of basic model assumptions are suggested.

JFM classification

Biological Fluid Dynamics: Biological Fluid Dynamics Biological Fluid Dynamics: Capsule/cell dynamics
Type
Papers
Information
Journal of Fluid Mechanics , Volume 736 , 10 December 2013 , pp. 351 - 365
Copyright
©2013 Cambridge University Press 

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