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Induction of protection in murine experimental models against Trichinella spiralis: an up-to-date review

Published online by Cambridge University Press:  12 March 2015

G. Ortega-Pierres ,
A. Vaquero-Vera ,
R. Fonseca-Liñán ,
R.M. Bermúdez-Cruz  and
R. Argüello-García
G. Ortega-Pierres*
Affiliation:
Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, México City, México
A. Vaquero-Vera
Affiliation:
Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, México City, México
R. Fonseca-Liñán
Affiliation:
Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, México City, México
R.M. Bermúdez-Cruz
Affiliation:
Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, México City, México
R. Argüello-García
Affiliation:
Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, México City, México
*
*E-mail: gortega@cinvestav.mx
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Abstract

The parasitic nematode Trichinella spiralis, an aetiological agent of the disease known as trichinellosis, infects wild and domestic animals through contaminated pig meat, which is the major source for Trichinella transmission. Prevention of this disease by interrupting parasite transmission includes vaccine development for livestock; however, major challenges to this strategy are the complexity of the T. spiralis life cycle, diversity of stage-specific antigens, immune-evasion strategies and the modulatory effect of host responses. Different approaches have been taken to induce protective immune responses by T. spiralis immunogens. These include the use of whole extracts or excretory–secretory antigens, as well as recombinant proteins or synthesized epitopes, using murine experimental models for trichinellosis. Here these schemes are reviewed and discussed, and new proposals envisioned to block the zoonotic transmission of this parasite.

Type
Review Articles
Information
Journal of Helminthology , Volume 89 , Issue 5 , September 2015 , pp. 526 - 539
Copyright
Copyright © Cambridge University Press 2015 

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