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Non-specific immunodepression by Nematospiroides dubius of concurrent responses to oxazolone and lipopolysaccharide

Published online by Cambridge University Press:  05 June 2009

Najah M. H. Alif  and
Jerzy M. Behnke
Najah M. H. Alif
Affiliation:
MRC Experimental Parasitology Research Group, Department of Zoology, University of Nottingham, University Park, Nottingham NG7 2RD
Jerzy M. Behnke
Affiliation:
MRC Experimental Parasitology Research Group, Department of Zoology, University of Nottingham, University Park, Nottingham NG7 2RD
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Abstract

Mice infected with Nematospiroides dubius show non-specific immunodeprcssion (NSID) of immune responses to concurrently administered antigens. This project investigated the factors influencing the response of oxazolone (T-dcpcndcnt antigen) and LPS (T-indcpcndent antigen) in infected mice. Depressed responses to both antigens were observed in mice infected with N. dubius, although the pattern of immunodeprcssion was influenced by both the level and the relative timing of infection and antigen presentation. Consistent NSID was only achieved when the mice were given the higher levels of infection and there was some evidence that NSID was more severe when infection preceded the administration of antigen by 14 days.In general, although NSID was significant, the degree of immunodepression was not considerable. It was concluded that the underlying mechanism of NSID was likely to be different from that enabling the parasite to survive in the intestine of the chronically infected host, and that altered physiology and host's modulation of the immune responses in heavily infected animals may have given rise to a general weakening of the immune system. It was suggested that future work should investigate NSID and parasitespecific immunodeprcssion locally in the intestine where parasite survival is likely to be determined by events at the nnicosal surface.

Type
Research Article
Information
Journal of Helminthology , Volume 58 , Issue 4 , December 1984 , pp. 301 - 311
Copyright
Copyright © Cambridge University Press 1984

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References

REFERENCES

Ali, N. M. H. & Behnke, J. M. (1984) Nonspecific immunodeprcssion by larval and adult Nematospiroides dubius. Parasitology, 88, 153–162.CrossRefGoogle ScholarPubMed
Ali, N. M. H. & Behnke, J. M. (1984) Nonspecific immunodeprcssion by larval and adult Nematospiroides dubius. Parasitology, 88, 153–162.CrossRefGoogle ScholarPubMed
Argyris, B. F. (1967 Role of macrophages in antibody production. Immune response to sheep red blood cells. Journal of Immunology, 99, 744–740.CrossRefGoogle ScholarPubMed
Asherson, G. L. & Ptak, W. (1968) Contact and delayed hypcrsensitivity in the mouse. I. Active sensitization and passive transfer. Immunology, 15, 405–416.Google ScholarPubMed
Asherson, G. L., Zembala, M., Perera, M. A. C. C., Mayhew, B. & Thomas, W. R. (1977) Production of immunity and unrcsponsiveness in the mouse by feeding contact sensitizing agents and the role of suppressor cells in the Peyer's patches, mescnsterie lymph nodes and other lymphoid tissues. Cellular Immunology, 33, 145–155.CrossRefGoogle ScholarPubMed
Befus, A. D. & Bienenstock, J. (1982) Factors involved in symbiosis and host resistance at the mucosa-parasitc interface. Progress in Allergy, 31, 76–177.Google ScholarPubMed
Behnke, J. M., Ali, N. M. H. & Jenkins, S. N. (1984) Survival of low level infections with Trichuris muris in mice concurrently infected with Nematospiroides dubius. Annals of Tropical Medicine and Parasitology (in press).CrossRefGoogle Scholar
Behnke, J. M., Hannah, J. & Pritchard, D. L. (1983) Nematospiroides dublus the mouse: evidence that adult worms depress the expression of homologous immunity. Parasite Immunology, 5, 397–408.CrossRefGoogle ScholarPubMed
Behnke, J. M. & Parish, H. A. (1979) Nematospiroldcs dubius: arrested development of larvae in immune mice. Experimental Parasitology, 47, 116–127.CrossRefGoogle ScholarPubMed
Behnke, J. M. & Wakelin, D. (1977) Nematospiroidcs dubius: stimulation of acquired immunity in inbred strains of mice. Journal of Ilelminthology, 51, 167–176.CrossRefGoogle ScholarPubMed
Behnke, J. M., Wakelin, D. & Wilson, M. M. (1978) Trichinella spiralis: delayed rejection in mice concurrently infected with Nematospiroides dubius. Experimental Parasitology, 46, 121–130.CrossRefGoogle ScholarPubMed
Bruna, C. D. & Xenia, B. (1976) Nippostrongylus brasiliensis in mice: reduction of worm burden and prolonged infection induced by presence of Nematospiroides dubius. Journal of Parasitology, 62, 490–491.CrossRefGoogle ScholarPubMed
Cayzer, C. J. R. & Dobson, C. (1983) Suppression of antibody production in mice given multiple concurrent infections with Nematospiroides dubius. International Journal for Parasitology, 13, 61–65.CrossRefGoogle ScholarPubMed
Collwell, D. A. & Wescott, R. B. (1973) Prolongation of egg production of Nippostrongylus brasiliensis in mice concurrently infected with Nematospiroides dubius. Journal of Parasitology, 59, 216.CrossRefGoogle Scholar
Greaves, M. F. & Moller, E. (1970) Studies on antigen-binding cells. I. The origin of reactive cells. Cellular Immunology, I, 372–385.CrossRefGoogle Scholar
Hagan, P. & Wakelin, D. (1982) Nematospiroides dubuis: Effect of infection on lymphocyte responses to Trichinella spiralis in mice. Experimental Parasitology, 54, 157–165.CrossRefGoogle Scholar
Haig, D. M., Lima, G. C. & Mota, I. (1980) Antibody suppression in mice infected with Nippostrongylus brasiliensis. Parasite Immunology, 2, 175–187.CrossRefGoogle ScholarPubMed
Hopkins, C. A. (1980) Immunity and Hymenolepis diminuta. In: Biology of the Tapeworm, Hymenolepis diminuta, pp. 551–614. (editor Arai, H. P.), Academic Press Inc., New York & London.CrossRefGoogle Scholar
Jenkins, D. C. (1975) The influence of Nematospiroides dubius on subsequent Nippostrongylus brasiliensis infections in mice. Parasitohgy, 71, 349–355.CrossRefGoogle ScholarPubMed
Jenkins, S. N. & Behnke, J. M. (1977) Impairment of primary expulsion of Trichuris muris in mice concurrently infected with Nematospiroides dubius. Parasitology, 75, 71–78.CrossRefGoogle ScholarPubMed
Lammie, P. J. & Katz, S. P. (1983) Immunorcgulation in experimental fllariasis. I. In vitro suppression of mitogen-induced blastogcncsis by adherent cells from jirds chronically infected with Brugia pahangi. Journal of Immunology, 130, 1381–1885.CrossRefGoogle ScholarPubMed
Mcelroy, P. J., Szewczuk, M. R. & Befus, A. D. (1983) Regulation of heterologous IgM, IgG and IgA antibody responses in mucosal-associatcd lymphoid tissues of Nippostrongylus brasiliensis infected mice. Journal of Immunology, 130, 435–441.CrossRefGoogle ScholarPubMed
Mitchell, G. F. (1982) The nude mouse in immunoparasitology. In: The nude mouse in experimental and clinical research, 2, 267–289. Academic Press, Inc.Google Scholar
Mitchell, G. F. & Miller, J. F. A. P. (1968) Cell to cell interaction in the immune response. II. The source of hcmolysin-forming cells in irradiated mice given bone marrow and thymus or thoracic duct lymphocytes. Journal of Experimental Medicine, 128, 821–837.CrossRefGoogle ScholarPubMed
Moller, G. (1965) 19S antibody production against soluble lipopolysaccharidc antigens by individual lymphoid cells in vitro. Nature, 207, 1166–1167.CrossRefGoogle ScholarPubMed
Ottesen, E. A., Weller, P. F. & Heck, L. (1977) Specific cellular immune unrcsponsiveness in human fllariasis. Immunology, 33, 413–421.Google Scholar
Portaro, J. K., Britton, S. & Ash, L. R. (1976) Brugia pahangi. Depressed mitogen reactivity in filarial infections in the jird, Meriones unguiculatus. Experimental Parasitology, 40, 438–446.CrossRefGoogle ScholarPubMed
Pownall, R. & Knapp, M. S. (1978) Circadian rhythmicity of delayed hypcrsensitivity to oxazolonc in the rat. Clinical Science and Molecular Medicine, 54, 447–449.Google ScholarPubMed
Pritchard, D. I., All, N. M. H. & Behnke, J. M. (1984) Analysis of the mechanism of immunodeprcssion following heterologous antigenic stimulation during concurrent infection with Nematospiroides dubius. Immunology, 51, 633–692.Google ScholarPubMed
Reed, N. D., Manning, J. K., Baker, P. J. & Ulrich, J. T. (1973) Analysis of thymus-independent immune responses using nude mice. In: Proceedings of the First International Workshop on Nude Mice, pp. 95–103. (Editors Rygaard, & Povlsen, , Gustav Fisher Verlag: Stuttgart.)Google Scholar
Robinson, M. & Behnke, J. M. (1983) Preliminary studies on the genetic control of immunity to Nematospiroides dubius in mice immunised by a 9 day abbreviated infection. Parasitology, 87, xiv.Google Scholar
Shimp, R. G., Crandall, R. B. & Crandall, C. A. (1975) Heligmosomoides polygyrus ( = Nematospiroides dubius): Suppression of antibody response to orally administered sheep crythrocytcs in infected mice. Experimental Parasitology, 38, 257–269.CrossRefGoogle ScholarPubMed
Sokal, R. R. & Rohlf, F. J. (1969 In: Biometry, p. 240. W. H. Freeman: San Francisco.Google Scholar
Wakelin, D. (1978) Immunity to intestinal parasites. Nature, 273, 617–620.CrossRefGoogle ScholarPubMed