Published online by Cambridge University Press: 18 November 2009
The epidemiology of parasitic infections may be profoundly influenced by infra-specific variations in infectivity for either intermediate or definitive hosts. Such variations will decide the basic ecology of the host-parasite relationship, and variations in virulence and pathogenicity therefore determine different patterns of disease. While some of the evidence of infra-specific variations has been derived from experimental studies, much of it has been recorded by those concerned with investigations of the epidemiology and transmission of parasitic infections and the practical aspects of their control. The unequivocal demonstration of genetic heterogeneity of certain parasites of medical importance has therefore resulted in a better understanding of their epidemiology and, in some cases, is leading to greater precision in attempts to control them.