Hostname: page-component-78c5997874-8bhkd Total loading time: 0 Render date: 2024-11-15T01:58:34.876Z Has data issue: false hasContentIssue false
  • English
  • Français

Studies with Brugia pahangi 10. An attempt to demonstrate the sharing of antigenic determinants between the worm and its hosts

Published online by Cambridge University Press:  05 June 2009

P. B. McGreevy ,
M. M. Ismail ,
T. M. Phillips  and
D. A. Denham
P. B. McGreevy
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London WCIE 7HT
M. M. Ismail
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London WCIE 7HT
T. M. Phillips
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London WCIE 7HT
D. A. Denham
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London WCIE 7HT
Get access Rights & Permissions [Opens in a new window]

Abstract

Infective stage Brugia pahangi that were reared in Aedes aegypti survived equally well in cats that hadpreviously been immunized against mosquito tissue and in a normal cat. The survival of third, fourth, juvenile, adult and microfilarial stages of B. paliangi that were recovered from cats was similar in jirds that had been immunized against cat antigens and in normal jirds. Host antigenic determinants were not detected on the surface of larvae in substantial amounts using fluorescent antibody techniques. It is unlikely that B. paliangi evades the immune response of its vertebrate hosts by masquerading as ‘self’ behind host antigens.

Type
Research Article
Information
Journal of Helminthology , Volume 49 , Issue 2 , June 1975 , pp. 107 - 113
Copyright
Copyright © Cambridge University Press 1975

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Bertram, D.S. (1966) Dynamics of parasitic equilibrium in cotton rat filariasis. In Advances in Parasitology 4, 255–319 (ed Dawes, B.) Academic Press: London.Google Scholar
Böyum, A. (1968) Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as crythrocyte-aggregating agents. Scandinavian Journal of clinical and laboratory Investigation, 21 Suppl. 97, 31–50.Google ScholarPubMed
Butts, J.A. and Rabalais, F.C. (1974) Successful jird-to-jird transfer of juvenile Brugia pahangi. Journal of Parasitology, 60, 436.CrossRefGoogle ScholarPubMed
Capron, A., Biguet, J., Vernes, A. and Afchain, D. (1968) Structure antigénique des helminthes. Aspects immunologiqucs des relations hote-parasite. Pathologie-Biologie 16, 121–138.Google Scholar
Coltortt, E.A. and Varela-dlaz, V.M. (1974) Echlnococcus granulosus: Penetration of macromolecules and their localization on the parasite membranes of cysts. Experimental Parasitology, 35, 225–231.CrossRefGoogle Scholar
Damian, R.T. (1964) Molecular mimicry: Antigen sharing by parasite and host and its consequences. American Naturalist, 98, 129–149.CrossRefGoogle Scholar
Denham, D.A., Ponnudurai, T., Nelson, G.S., Guy, F. and Rogers, R. (1972) Studies with Brugia pahangi. I. Parasitological observations on primary infections of cats (Felis catiis). International Journal for Parasitology, 2, 239–247.CrossRefGoogle Scholar
Howell, M.J. (1973) The resistance of cysts ofStictodora larl (Trematoda: Heterophyidae) to encapsulation by cells of the fish host. International Journal for Parasitology, 3, 653–659.CrossRefGoogle Scholar
Hughes, D.L. and Harness, E. (1973a) Attempts to demonstrate a ‘host antigen’ effect by the experimental transfer of adult Fasciola hepatica into recipient animals immunised against the donor. Research in Veterinary Science, 14, 151–154.CrossRefGoogle ScholarPubMed
Hughes, D.L. and Harness, E. (1973b) The experimental transfer of immature Fasciola hepatica from donor mice and hamsters to rats immunised against the donors. Research in Veterinary Science, 14, 220–222.CrossRefGoogle ScholarPubMed
Mccall, J.W., Malone, J.B., Ah, H.-S. and Thompson, P. (1973) Mongolian jirds (Meriones unguiculatus) infected with Brugia pahangi by the intraperitoneal route: A rich source of developing larvae, adult filariae, and microfilariae. Journal of Parasitology, 59, 436.CrossRefGoogle ScholarPubMed
Nelson, G.S. (1966) The pathology of filarial infections. Helmlnthological Abstracts, 35, 311–336.Google Scholar
Oliver-Gonzales, G.L. (1946) Functional antigens in helminths. Journal of infectious Diseases, 78, 232–237.CrossRefGoogle Scholar
Perez, H. and Terry, R.J. (1973) The killing of adult Schistosoma mansonl in vitro in the presence of antisera to host antigenic determinants and peritoneal cells. International Journal for Parasitology, 3, 499–503.CrossRefGoogle ScholarPubMed
Rickard, M.D. (1974) Hypothesis for the long term survival of Taenia pisiformis cysticerci in rabbits. Zeltschrift für Parasitenkunde, 44, 203–209.CrossRefGoogle Scholar
Schacher, J.F. (1962) Developmental stages of Brugia pahangiin the final host. Journal of Parasitology 48, 693–706.CrossRefGoogle ScholarPubMed
Smithers, S.R., Terry, R.J. and Hockley, D.J. (1969) Host antigens in schistosomiasis. Proceedings of the Royal Society B, 171, 483–494.Google ScholarPubMed
Soulsby, E.J.L. (1970) Studies of the blood group and heterophile antigenic determinants of the cuticle of larvae of Ascaris suum. H. D. Srivastava Commemoration Volume, Prem, Lucknow, pp. 361–374.Google Scholar
Soulsby, E.J.L. and Coombs, R.R.A. (1959) Studies on blood group substances associated with Ascaris lumbricoides. Parasitology, 49, 505–510.CrossRefGoogle Scholar
Varela-dlaz, V.M., Williams, J.F., Coltorti, E.A. and Williams, C.S.F. (1974) Survival of cysts of Echinococcus granulosus after transplant into homologous and heterologous hosts. Journal of Parasitology, 60, 608–612.CrossRefGoogle Scholar
Williams, J.F. and Soulsby, E.J.L. (1970) Antigenic analysis of the developmental stages of Ascaris suum. II. Host components. Experimental Parasitology, 27, 362–367.CrossRefGoogle Scholar
Wilson, T. and Ramachandran, C.P. (1971) Brugia infections in man and animals: long-term observations on microfilaraemia and estimates of the efficiency of transmission from mosquito vector to definitive host. Annals of tropical Medicine and Parasitology, 65, 525–546.CrossRefGoogle ScholarPubMed