Hostname: page-component-78c5997874-8bhkd Total loading time: 0 Render date: 2024-11-10T06:05:24.975Z Has data issue: false hasContentIssue false
  • English
  • Français

Comparison of the live vaccine potential of different geographic isolates of Schistosoma mansoni

Published online by Cambridge University Press:  05 June 2009

Q. D. Bickle  and
M. J. Doenhoff
Q. D. Bickle
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, Winches Farm Laboratories, 395 Hatfield Road, St Albans, Herts., AL40XQ, England
M. J. Doenhoff
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, Winches Farm Laboratories, 395 Hatfield Road, St Albans, Herts., AL40XQ, England
Get access Rights & Permissions [Opens in a new window]

Abstract

We have investigated the capacity of irradiated larvae of each of six different isolates of Schistosoma mansoni to protect mice against challenge infections from the homologous or a different isolate. The isolates differed in respect of their geographic origins, and in the lengths of time they had been maintained in the laboratory. All isolates induced significant protection against unattenuated challenge infections, and neither the degree of geographic disimilarity between vaccinating and challenge parasites, nor the numbers of laboratory cycles, appeared to influence the degree of protection induced by irradiation-attenuated larvae.

Keywords

Schistosoma mansonigeographic isolatesmouseirradiated vaccine
Type
Research Papers
Information
Journal of Helminthology , Volume 61 , Issue 3 , September 1987 , pp. 191 - 195
Copyright
Copyright © Cambridge University Press 1987

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Basch, P. F. (1976) Intermediate host specificity in Schistosoma mansoni. Experimental Parasitology, 39, 150–169.CrossRefGoogle ScholarPubMed
Bickle, Q. D. & Andrews, B. J. (1985) Resistance following drug attenuation (Ro 11–3128 or oxamniquine) of early Schistosoma mansoni infections in mice. Parasitology, 90, 325–338.CrossRefGoogle ScholarPubMed
Bickle, Q. D., Andrews, B. J., Doenhoff, M. J., Ford, M. J. & Taylor, M. G. (1985) Resistance against Schistosoma mansoni induced by highly irradiated infections: studies on species specificity of immunization and attempts to transfer resistance. Parasitology, 90, 301–312.CrossRefGoogle ScholarPubMed
Bickle, Q. D., Taylor, M. G., Doenhoff, M. J. & Nelson, G. S. (1979) Immunization of mice with gamma-irradiated, intramuscularly injected schistosomula of Schistosoma mansoni. Parasitology, 79, 209–222.CrossRefGoogle ScholarPubMed
Fletcher, M., Lo Verde, P. T. & Woodruff, D. S. (1981) Genetic variation in Schistosoma mansoni enzyme polymorphisms in populations from Africa, South West Asia, South America and the West Indies. American Journal of Tropical Medicine and Hygiene, 30, 406–421.CrossRefGoogle Scholar
Ford, M. J., Bickle, Q. D. & Taylor, M. G. (1984) Immunization of rats against Schistosoma mansoni using irradiated cercariae, lung schistosomula and liver stage worms. Parasitology, 89, 327–344.CrossRefGoogle ScholarPubMed
Lo Verde, P. T., De Wald, J., Minchella, D. J., Bosshardt, S. C. & Damian, R. T. (1985) Evidence for host-induced selection in Schistosoma mansoni. Journal of Parasitology, 71, 297–301.CrossRefGoogle ScholarPubMed
Taylor, M. G., James, E. R., Nelson, G. S., Bickle, Q., Dunne, D. W. & Dobinson, A. R. (1977) Modification of the pathogenicity of Schistosoma mattheei for sheep by passage of the parasite in hamsters. Journal of Helminthology, 51, 337–345.CrossRefGoogle ScholarPubMed
Warren, K. S. (1967) A comparison of Puerto Rican, Brazilian, Egyptian and Tanzanian strains of Schistosoma mansoni in mice: penetration of cercariae, maturation of schistosomes and production of liver disease. Transactions of the Royal Society of Tropical Medicine and Hygiene, 61, 795–802.CrossRefGoogle ScholarPubMed