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Hymenolepis murissylvatici: humoral response in intestinal lavages of the mouse

Published online by Cambridge University Press:  05 June 2009

E. Van Der Vorst ,
H. Dhont ,
C. Van Haeren ,
R. Deceunynck  and
P. H. De Rycke
E. Van Der Vorst
Affiliation:
Laboratory of Zoophysiology, State University of Gent, K.L. Ledeganckstraat 35, B–9000 Gent, Belgium
H. Dhont
Affiliation:
Laboratory of Zoophysiology, State University of Gent, K.L. Ledeganckstraat 35, B–9000 Gent, Belgium
C. Van Haeren
Affiliation:
Laboratory of Zoophysiology, State University of Gent, K.L. Ledeganckstraat 35, B–9000 Gent, Belgium
R. Deceunynck
Affiliation:
Laboratory of Zoophysiology, State University of Gent, K.L. Ledeganckstraat 35, B–9000 Gent, Belgium
P. H. De Rycke
Affiliation:
Laboratory of Zoophysiology, State University of Gent, K.L. Ledeganckstraat 35, B–9000 Gent, Belgium
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Abstract

Hymenolepis murissylvatici elicits a humoral response in serum and in the intestine of the mouse from which it is immunologically rejected. In serum, significant differences were recorded 3 days after reinfection, while in intestinal lavages it takes place from day 9 after reinfection. In serum the response is largely the result of IgG and IgM antibodies whereas in the intestine, IgA is the most abundant antibody. Although specific IgE could not be demonstrated in serum, it was present in intestinal lavages, although rather late (i.e. day 14 after reinfection). Treatment of young worms in vitro both with immune serum or intestinal lavages had no apparent effect on their viability. Immune serum produced a complement independent precipitation on the surface of the worms in vitro. This reaction did not affect viability or infectivity of the parasite, as demonstrated by the successful implantation of treated worms in recipient mice. The above-mentioned results, together with the knowledge that the Hymenolepis model has no tissue stages and causes no tissue damage, make it probable that further study of this model will reveal some specific intestinal immunological reactions.

Keywords

Hymenolepis murissylvaticiimmunoglobulinshumoral responsemouseintestine
Type
Research Article
Information
Journal of Helminthology , Volume 63 , Issue 1 , March 1989 , pp. 25 - 31
Copyright
Copyright © Cambridge University Press 1989

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