Hostname: page-component-78c5997874-m6dg7 Total loading time: 0 Render date: 2024-11-14T04:24:00.600Z Has data issue: false hasContentIssue false
  • English
  • Français

The Influence of Dietary Protein Level upon the Response of Mice Infected with Schistosoma mansoni to Treatment with Niridazole (Ambilhar)*

Published online by Cambridge University Press:  05 June 2009

A. M. Fadl
A. M. Fadl
Affiliation:
Department of Human NutritionLondon School of Hygiene and Tropical Medicine
Get access Rights & Permissions [Opens in a new window]

Extract

1. The influence of diets having different protein values on the schistosomicidal effect of Ambilhar has been investigated in mice.

2. Mice placed on these diets throughout the period of infection and then treated, reached differently. Low protein diets produced fewer and smaller worms which were more susceptible to the drug.

3. Mice maintained on an adequate diet were shifted to diets of varying protein values a few days before treatment. In these, drug treatment was more satisfactory in animals fed the high protein regimen.

4. Female worms were more affected by drug treatment than the males.

Type
Research Article
Information
Journal of Helminthology , Volume 45 , Issue 2-3 , June 1971 , pp. 117 - 122
Copyright
Copyright © Cambridge University Press 1971

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bell, D. R., 1964.—“Diet and therapy in Bilharzia.” Lancet, 1, 643–644.CrossRefGoogle ScholarPubMed
Bell, D. R., 1965.—“in: Proc. Cent. Afr. Sci. Med. Congo, Lusaka, N. Rhodesia. Oxford, Pergamon Press.Google Scholar
Bueding, E., Peters, L. and Waite, J. F., 1947.—“Effect of 2-methyl-1, 4 nephthaquinone on glycolysis of Schistosoma mansoni.” Proc. Soc. exp. Biol. Med., 64, 111–113.CrossRefGoogle ScholarPubMed
De Witt, W. B., Oliver-Gonzales, J. and Medina, E., 1962.—“in: Bilharziasis. Eds. Wolstenholme, G. E. W and O'Connor, MLondon, J. & A. Churchill.Google Scholar
Faigle, J. W. and Keberle, H., 1969.—“Metabolism of niridazole in various species, including man.” Ann. N. Y. Acad. Sci., 160, 544–557.CrossRefGoogle ScholarPubMed
Jordan, P., 1969.—“Factors affecting result of chemotherapy in schistosomiasis.” Ann. N. Y. Acad. Sci., 160, 602–611.CrossRefGoogle ScholarPubMed
Lambert, C. R., 1964.—“Chemotherapy of experimental Schistosoma mansoni infections with a nitrothiazole derivative, CIBA 32, 644–Ba.” Ann. trop. Med. Parasit., 58, 292–303.CrossRefGoogle ScholarPubMed
Luttermoser, G. W. and De Witt, W. B., 1961.—“Enhancement of Stibophen (Fuadin) activity against Schistosoma mansoni in mice by feeding purified semi-synthetic diets.” Amer. J. trop. Med. Hyg., 10, 541–546.CrossRefGoogle Scholar
Nelson, G. S. and Saoud, M. F. A., 1966.—“The daily egg output of Schistosoma mansoni in rhesus monkeys.” Trans. R. Soc. trop. Med. Hyg., 60, 429–430.CrossRefGoogle Scholar
Platt, B. S., Miller, D. S. and Payne, P. R., 1961.—in: Recent advances in human nutrition. Ed. Brock., J. FLondon, J. & A. Churchill.Google Scholar
Smithers, S. R. and Terry, R. J., 1965.—“The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of the adult worms.” Parasitology, 55, 695–700.CrossRefGoogle ScholarPubMed
Striebel, H., 1969.—“The effects of niridazole in experimental schistosomiasis.” Ann. N. Y. Acad. Sci., 160, 491–518.CrossRefGoogle ScholarPubMed
Taylor, M., 1970.—Ph.D. Thesis. University of London.Google Scholar
Webbe, G., 1962.—“The transmission of Schistosoma haensatobium in an area of Lake Province, Tanganyika.” Bull. Wld Hlth Org., 27, 59–85.Google Scholar
World Health Organization, 1966.—Chemotherapy of Bilharzia. Tech. Rep. Series no. 317. Geneva.Google Scholar