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The role of macrophages on the expression of sex difference in the susceptibility to Brugia pahangi infection in C57BL/6 mice

Published online by Cambridge University Press:  05 June 2009

Hirokuni Nakanishi ,
Yoichiro Horii  and
Koichiro Fujita
Hirokuni Nakanishi
Affiliation:
Department of Medical Zoology, Nagasaki University School of Medicine, Sakamoto-machi, Nagasaki 852, Japan;
Yoichiro Horii*
Affiliation:
Department of Medical Zoology, Nagasaki University School of Medicine, Sakamoto-machi, Nagasaki 852, Japan;
Koichiro Fujita
Affiliation:
Department of Medical Zoology, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, Tokyo 113, Japan
*
* Author for coresspondence.
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Abstract

The role of macrophages or eosinophils on the expression of sex difference in the susceptibility to a primary Brugia pahangi infection in C57BL/6 mice was investigated by using a macrophage blockade technique (carbon treatment) or a histamine type 1 (H1) receptor antagonist (promethazine). Carbon treatment remarkably inhibited macrophage exudation, reduced the resistance of female mice, and completely abolished sex difference in the susceptibility to B. pahangi infection. Although promethazine treatment inhibited eosinophil exudation, it caused only a little increase (not significant) in the recovery rate of worms. These results suggest that macrophages have more important role(s) than do eosinophils on the expression of sex difference in the susceptibility to a primary B. pahangi infection in C57BL/6 mice.

Keywords

Brugia pahangisusceptibilitysex differencemacrophageeosinophilC57BL/6 mouse
Type
Research Article
Information
Journal of Helminthology , Volume 63 , Issue 3 , September 1989 , pp. 213 - 217
Copyright
Copyright © Cambridge University Press 1989

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