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Trichinella spiralis: inflammation modulator

Published online by Cambridge University Press:  21 September 2020

Jing Ding ,
Xiaolei Liu ,
Xue Bai ,
Yang Wang ,
Jian Li ,
Chun Wang ,
Shicun Li ,
Mingyuan Liu  and
Xuelin Wang Open the ORCID record for Xuelin Wang [Opens in a new window]
Jing Ding
Affiliation:
Key Laboratory for Zoonoses Research, Ministry of Education, Institute of Zoonoses, College of Veterinary Medicine, Jilin University, OIE Collaborating Center on Foodborne Parasites in Asian-Pacific Region, Changchun130062, P.R. China
Xiaolei Liu
Affiliation:
Key Laboratory for Zoonoses Research, Ministry of Education, Institute of Zoonoses, College of Veterinary Medicine, Jilin University, OIE Collaborating Center on Foodborne Parasites in Asian-Pacific Region, Changchun130062, P.R. China
Xue Bai
Affiliation:
Key Laboratory for Zoonoses Research, Ministry of Education, Institute of Zoonoses, College of Veterinary Medicine, Jilin University, OIE Collaborating Center on Foodborne Parasites in Asian-Pacific Region, Changchun130062, P.R. China
Yang Wang
Affiliation:
Key Laboratory for Zoonoses Research, Ministry of Education, Institute of Zoonoses, College of Veterinary Medicine, Jilin University, OIE Collaborating Center on Foodborne Parasites in Asian-Pacific Region, Changchun130062, P.R. China
Jian Li
Affiliation:
Key Laboratory for Zoonoses Research, Ministry of Education, Institute of Zoonoses, College of Veterinary Medicine, Jilin University, OIE Collaborating Center on Foodborne Parasites in Asian-Pacific Region, Changchun130062, P.R. China
Chun Wang
Affiliation:
Key Laboratory for Zoonoses Research, Ministry of Education, Institute of Zoonoses, College of Veterinary Medicine, Jilin University, OIE Collaborating Center on Foodborne Parasites in Asian-Pacific Region, Changchun130062, P.R. China
Shicun Li
Affiliation:
Key Laboratory for Zoonoses Research, Ministry of Education, Institute of Zoonoses, College of Veterinary Medicine, Jilin University, OIE Collaborating Center on Foodborne Parasites in Asian-Pacific Region, Changchun130062, P.R. China
Mingyuan Liu
Affiliation:
Key Laboratory for Zoonoses Research, Ministry of Education, Institute of Zoonoses, College of Veterinary Medicine, Jilin University, OIE Collaborating Center on Foodborne Parasites in Asian-Pacific Region, Changchun130062, P.R. China
Xuelin Wang*
Affiliation:
Key Laboratory for Zoonoses Research, Ministry of Education, Institute of Zoonoses, College of Veterinary Medicine, Jilin University, OIE Collaborating Center on Foodborne Parasites in Asian-Pacific Region, Changchun130062, P.R. China
*
Author for correspondence: X. Wang, E-mail: xuelin@jlu.edu.cn
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Abstract

The hygiene hypothesis posits that the decreased incidence of parasitic infection in developed countries may underlie an increased prevalence of allergic and autoimmune diseases in these countries. As unique inflammation modulator of intracellular parasitism, Trichinella spiralis, or its excretory–secretory (ES) product, shows improved responses to allergies, autoimmune diseases, inflammatory bowel disease, type 1 diabetes, rheumatic arthritis and autoimmune encephalomyelitis by exerting immunomodulatory effects on both innate and adaptive immune cells in animal models. Research has shown that T. spiralis differs from other helminths in manipulation of the host immune response not only by well-known characteristics of its life cycle, but also by its inflammation modulation pathway. How the parasite achieves inflammation modulation has not been fully elucidated yet. This review will generalize the mechanism and focuses on ES immunomodulatory molecules of T. spiralis that may be important for developing new therapeutics for inflammatory disorders.

Keywords

Trichinella spiralisexcretory–secretory (ES)immunomodulatoryinflammatory disorders
Type
Review Article
Information
Journal of Helminthology , Volume 94 , 2020 , e193
Copyright
Copyright © The Author(s), 2020. Published by Cambridge University Press

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