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Presumed reduction of vestibular function in unilateral Menière's disease with aminoglycoside eardrops

Published online by Cambridge University Press:  29 June 2007

Andrew P. Bath ,
Rory M. Walsh  and
Manohar L. Bance
Andrew P. Bath
Affiliation:
Department of Otolaryngology, The Toronto Hospital, Toronto, Ontario, Canada
Rory M. Walsh
Affiliation:
Department of Otolaryngology, The Toronto Hospital, Toronto, Ontario, Canada
Manohar L. Bance*
Affiliation:
Department of Otolaryngology, The Toronto Hospital, Toronto, Ontario, Canada
*
Address for correspondence: Dr M. Bance, Department of Otolaryngology, The Toronto Hospital, General Division, EN7-221, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada. Fax: (416) 340 5116
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Abstract

We report the first case in the world literature of deliberate ablation of vestibular function in unilateral Meniere's disease with aminoglycoside eardrops (Garasone).

These findings give conclusive proof that Garasone eardrops, and by implication, all topical aminoglycoside ear drops can be vestibulotoxic in the presence of a tympanic membrane defect. The lower concentration of gentamicin in Garasone, in comparison to the standard intratympanic preparations for chemical ablation of vestibular function, may also offer a reduction in the potential risk of cochleotoxocity.

Keywords

AminoglycosidesMenière's diseaseVertigoDisease management
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 113 , Issue 10 , October 1999 , pp. 916 - 918
Copyright
Copyright © JLO (1984) Limited 1999

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