Hostname: page-component-78c5997874-xbtfd Total loading time: 0 Render date: 2024-11-14T06:04:36.914Z Has data issue: false hasContentIssue false
  • English
  • Français

Salivary neoplasms of the palate: a flow cytometric and clinicopathological analysis

Published online by Cambridge University Press:  29 June 2007

Rosario Carrillo ,
John G. Batsakis ,
Randal Weber ,
Mario A. Luna  and
Adel K. El-Naggar
Rosario Carrillo
Affiliation:
Department of Anatomic Pathology, Hospital Ramony Cajal, Madrid, Spain, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas.
John G. Batsakis*
Affiliation:
Department of the Departments of Pathology, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas.
Randal Weber
Affiliation:
Department of Head and Neck Surgery, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas.
Mario A. Luna
Affiliation:
Department of the Departments of Pathology, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas.
Adel K. El-Naggar
Affiliation:
Department of the Departments of Pathology, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas.
*
John G. Batsakis, M.D., The University of Texas, M.D. Anderson Cancer Center, Department of Pathology,1515 Holcombe Blvd., Box 85, Houston, Texas 77030.
Get access Rights & Permissions [Opens in a new window]

Abstract

In order to test the clinical and prognostic significance of flow cytometrically assessed DNA content in minor salivary gland tumours we evaluated 75 neoplasms of the palate, 55 of which were carcinomas. Benign neoplasms were exclusively DNA diploid with low S-phase fractions while 22 per cent of malignant tumours manifested a DNA aneuploidy and 23.5 per cent high S-phase fractions (>5 per cent). Significant statistical correlations between DNA content and tumour size, histological grade, lymph node metastasis and lethality were observed. Our findings suggest a potentially important role for flow-cytometry in the evaluation of these neoplasms.

Keywords

Flow cytometryDNASalivary gland neoplasmsPalateAdenocarcinoma, terminal ductCarcinoma, adenoid cystic
Type
Pathology in Focus
Information
The Journal of Laryngology & Otology , Volume 107 , Issue 9 , September 1993 , pp. 858 - 861
Copyright
Copyright © JLO (1984) Limited 1993

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Batsakis, J. G., Luna, M. A. (1990) Histologic grading of salivary gland neoplasms: I. Mucoepidermoid carcinomas. Annals of Otology, Rhinology and Laryngology 99: 835–838.CrossRefGoogle Scholar
Batsakis, J. G., El-Naggar, A. K. (1991) Terminal duct adenocarcinomas of salivary tissues. Annals of Otology, Rhinology and Laryngology 100: 251–253.Google Scholar
El-Naggar, A. K., Batsakis, J. G., Luna, M. A., McLemore, D., Byers, R. M. (1990) DNA flow cytometry of acinic cell carcinomas of major salivary glands. Journal of Laryngology and Otology 104: 410–416.Google Scholar
Eneroth, C. M., Zetterberg, A. (1973) Nuclear DNA content as a criterion of malignancy in salivary gland tumors of the oral cavity. Acta Otolaryngologica 75: 296–298.Google Scholar
Eneroth, C. M., Zetterberg, A. (1974) Microspectrophotometric DNA analysis of malignant salivary gland tumors. Acta Otolaryngologica 77: 289–294.CrossRefGoogle Scholar
Franzén, G., Klausen, O. G., Grenko, R. T, Carstensen, J., Nordenskjold, B. (1991) Adenoid cystic carcinoma: DNA as a prognostic indicator. Laryngoscope 101: 669–673.Google Scholar
Hamper, K., Schimmelpenning H., Caselitz, J., Arps, H., Berger, J., Askensten, U., Auer, G., Seifert, G. (1989) Mucoepidermoid tumors of the salivary glands. Correlation of cytophotometrical data and prognosis. Cancer 63: 708–717.3.0.CO;2-Z>CrossRefGoogle ScholarPubMed
Hamper, K., Mausch, H. E., Caselitz, J., Arps, H. A., Berger, J., Askensten, U., Auer, G., Seifert, G. (1990) Acinic cell carcinoma of the salivary glands: the prognostic relevance of DNA cytophotometry in a retrospective study of long duration (1965–1987). Oral Surgery, Oral Medicine, Oral Pathology 69: 68–75.Google Scholar
Hedley, D. W., Friedlander, M. L., Taylor, I. W., Rugg, C. A., Musgrove, E. A. (1983) Method for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry. Journal of Histochemistry and Cytochemistry 31: 1333–1335.CrossRefGoogle ScholarPubMed
Kaplan, E. L., Meier, P. (1958) Nonparametric estimation from incomplete observations. Journal of the American Statistical Association 53: 457–481.CrossRefGoogle Scholar
Kimura, O., Kijima, T, Moniwaki, S., Hoshino, K., Yonekawa, M., Sugezawa, A., Kaibara, N. (1992) DNA index as a significant indicator of lymph node metastasis and local recurrence of rectal cancer. Diseases of the Colon and Rectum 35: 1130–1134.Google Scholar
Kino, I., Richart, R. M., Lattes, R. (1973) Nuclear DNA in salivary gland tumors. II. Adenocytic carcinomas. Archives of Pathology and Laboratory Medicine 95: 325–329.Google Scholar
McLemore, D. D., El-Naggar, A. K., Stephens, L. C., Jardine, J. H. (1990) Modified methodology to improve flow cytometric DNA histograms from paraffin-embedded material. Stain Technology 65: 279–291.Google Scholar
Slootweg, P. J., Muller, H. (1987) Low-grade adenocarcinoma of the oral cavity. A comparison between the terminal duct and the papillary type. Journal of Cranio-Maxillo-Facial Surgery 15: 359–364.Google Scholar
Spiro, R. H., Koss, L. G., Hajdu, S. I., Strong, E. W. (1973) Tumors of minor salivary origin: a clinicopathologic study of 492 cases. Cancer 31: 117–129.3.0.CO;2-7>CrossRefGoogle ScholarPubMed
Spiro, R. J., Thaler, H. T., Hicks, W. F., Kher, U. A., Huvos, A. H., Strong, E. W. (1991) The importance of clinical staging of minor salivary gland carcinoma. American Journal of Surgery 162: 330–336.Google Scholar
Szanto, P. A., Luna, M. A., Tortoledo, M. E., White, R. A. (1984) Histologic grading of adenoid cystic carcinoma of the salivary glands. Cancer 54: 1062–1069.3.0.CO;2-E>CrossRefGoogle ScholarPubMed