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Chondromyxoid fibroma of skull base: a tumour prone to local recurrence

Published online by Cambridge University Press:  29 June 2007

T. W. H. Shek ,
W. C. G. Peh  and
G. Leung
T. W. H. Shek*
Affiliation:
Department of Pathology, University of Hong Kong, Queen Mary Hospital, Hong Kong.
W. C. G. Peh
Affiliation:
Department of Diagnostic Radiology, University of Hong Kong, Queen Mary Hospital, Hong Kong.
G. Leung
Affiliation:
Department of Surgery, University of Hong Kong, Queen Mary Hospital, Hong Kong.
*
Dr Tony W. H. Shek, Department of Pathology, University of Hong Kong, Queen Mary Hospital, Hong Kong. Fax: (852) 2872 8098
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Abstract

Chondromyxoid fibroma of the skull base is extremely uncommon. Sometimes involvement of the nasal cavity may occur and the patients may present with nasal symptoms. The biological behaviour of this tumour has not been well studied, primarily because of the limited number of reported cases and the short duration of followup. We report a histologically confirmed case of chondromyxoid fibroma of the skull base that recurred repeatedly over a 10-year period after the initial operation. Histologically it showed identical morphology to the original tumour with no evidence of histological progression or dedifferentiation. Ultrastructurally, the spindle tumour cells in the fibromyxoid area showed dual chondroblastic and fibroblastic differentiation, suggesting that these spindle fibroblastic cells and the better differentiated chondroid cells were of the same cell type with different histological morphology.

Keywords

Chondromyxoid fibromaSkull baseNasal cavityElectron microscopy
Type
Pathology in Focus
Information
The Journal of Laryngology & Otology , Volume 113 , Issue 4 , April 1999 , pp. 380 - 385
Copyright
Copyright © JLO (1984) Limited 1999

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