Hostname: page-component-cd9895bd7-gxg78 Total loading time: 0 Render date: 2024-12-27T09:49:08.831Z Has data issue: false hasContentIssue false
  • English
  • Français

Clinicopathological determinants of positron emission tomography computed tomography fluorodeoxyglucose standardised uptake value in head and neck carcinoma

Published online by Cambridge University Press:  21 June 2013

E Ozer ,
B Naiboglu ,
U Karapinar ,
A Agrawal ,
H G Ozer  and
D E Schuller
E Ozer
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Arthur G James Cancer Hospital and Richard J Solove Research Institute, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, USA
B Naiboglu*
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Haydarpasa Numune Educational Hospital, Istanbul, Turkey
U Karapinar
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Denizli Military Hospital, Turkey
A Agrawal
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Arthur G James Cancer Hospital and Richard J Solove Research Institute, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, USA
H G Ozer
Affiliation:
Department of Biomedical Informatics, Arthur G James Cancer Hospital and Richard J Solove Research Institute, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, USA
D E Schuller
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Arthur G James Cancer Hospital and Richard J Solove Research Institute, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, USA
*
Address for correspondence: Dr B Naiboglu, Acıbadem Yaprak Sokak No 39/8, Istanbul, Turkey Fax: 00902163360565 E-mail: drbnaib@yahoo.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Background:

Although positron emission tomography computed tomography has proven diagnostic and staging value in head and neck carcinoma, it does not have optimal sensitivity or specificity. The positron emission tomography computed tomography fluorodeoxyglucose standardised uptake value has been shown to be associated with carcinoma stage. This study evaluated the impact of major clinicopathological factors on the standardised uptake value at the primary site and at neck lymph node metastases.

Subjects and methods:

Two hundred and forty-three oral cavity and laryngopharyngeal carcinoma patients who underwent positron emission tomography computed tomography were included. Correlation between the positron emission tomography computed tomography standardised uptake value and various clinicopathological factors was analysed.

Results:

A positive correlation was found between the standardised uptake value and the size and depth of tumour infiltration, and lymph node positivity. Higher standardised uptake values were seen for more advanced tumour stages. The presence of perineural invasion, lymphatic invasion and extracapsular spread were all associated with increased standardised uptake values.

Conclusion:

Most of the clinicopathological features of head and neck carcinoma which are well known to be poor prognostic factors have a significant impact on positron emission tomography computed tomography fluorodeoxyglucose standardised uptake value.

Keywords

Head And Neck NeoplasmsComputed Tomography and Positron-Emission Tomography
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 127 , Issue 7 , July 2013 , pp. 676 - 680
Copyright
Copyright © JLO (1984) Limited 2013 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Presented at the American Academy of Otolaryngology–Head and Neck Surgery Meeting, 28 September 2010, Boston, Massachusetts, USA

References

1Torizuka, T, Tanizaki, Y, Kanno, T, Futatsubashi, M, Naitou, K, Ueda, Y et al. Prognostic value of 18F-FDG PET in patients with head and neck squamous cell cancer. AJR Am J Roentgenol 2009;192:156–60CrossRefGoogle ScholarPubMed
2Minn, H, Lapela, M, Klemi, PJ, Grénman, R, Leskinen, S, Lindholm, P et al. Prediction of survival with fluorine-18-fluoro-deoxyglucose and PET in head and neck cancer. J Nucl Med 1997;38:1907–11Google ScholarPubMed
3Halfpenny, W, Hain, SF, Biassoni, L, Maisey, MN, Sherman, JA, McGurk, M. FDG-PET: a possible prognostic factor in head and neck cancer. Br J Cancer 2002;86:512–6CrossRefGoogle ScholarPubMed
4Allal, AS, Dulguerov, P, Allaoua, M, Haenggeli, CA, El-Ghazi el, A, Lehmann, W et al. Standardized uptake value of 2-[(18)F] fluoro-2-deoxy-D-glucose in predicting outcome in head and neck carcinomas treated by radiotherapy with or without chemotherapy. J Clin Oncol 2002;20:1398–404CrossRefGoogle ScholarPubMed
5Warburg, O. On the origin of cancer cells. Science 1956;123:309–14CrossRefGoogle ScholarPubMed
6Kato, H, Kuwano, H, Nakajima, M, Miyazaki, T, Yoshikawa, M, Ojima, H et al. Comparison between positron emission tomography and computed tomography in the use of the assessment of esophageal carcinoma. Cancer 2002;94:921–8CrossRefGoogle ScholarPubMed
7Van Baardwijk, A, Dooms, C, van Suylen, RJ, Verbeken, E, Hochstenbag, M, Dehing-Oberije, C et al. The maximum uptake of (18)F-deoxyglucose on positron emission tomography scan correlates with survival, hypoxia inducible factor-1alpha and GLUT-1 in non-small cell lung cancer. Eur J Cancer 2007;43:1392–98CrossRefGoogle ScholarPubMed
8Suzuki, H, Fukuyama, R, Hasegawa, Y, Tamaki, T, Nishio, M, Nakashima, T et al. Tumor thickness, depth of invasion, and Bcl-2 expression are correlated with FDG-uptake in oral squamous cell carcinomas. Oral Oncol 2009;45:891–7CrossRefGoogle ScholarPubMed
9Vansteenkiste, JF, Stroobants, SG, Dupont, PJ, De Leyn, PR, Verbeken, EK, Deneffe, GJ et al. Prognostic importance of the standardized uptake value on 18F-fluoro-2-deoxy-glucose-positron emission tomography scan in non-small-cell lung cancer: an analysis of 125 cases. J Clin Oncol 1999;24:3201–6CrossRefGoogle Scholar
10Haberkorn, U, Strauss, LG, Reisser, C, Haag, D, Dimitrakopoulou, A, Ziegler, S et al. Glucose uptake, perfusion, and cell proliferation in head and neck tumors: relation of positron emission tomography to flow cytometry. J Nucl Med 1991;32:1548–55Google ScholarPubMed
11Minn, H, Clavo, AC, Grenman, R, Wahl, RL. In vitro comparison of cell proliferation kinetics and uptake of tritiated fluorodeoxyglucose and L-methionine in squamous-cell carcinoma of the head and neck. J Nucl Med 1995;36:252–8Google ScholarPubMed
12Kubota, K. From tumor biology to clinical Pet: a review of positron emission tomography (PET) in oncology. Ann Nucl Med 2001;15:471–86CrossRefGoogle ScholarPubMed
13Feng, R, Li, MH, Kong, L, Shi, F, Yang, GR, Yu, JM. Correlation between PET-CT 18FDG uptake in primary lesions and clinicopathological parameters in esophageal carcinoma patients [in Chinese]. Zhonghua Zhong Liu Za Zhi 2009;31:452–4Google ScholarPubMed
14Liao, CT, Wang, HM, Chang, JT, Lin, CY, Ng, SH, Huang, SF et al. Influence of pathological nodal status and maximal standardized uptake value of the primary tumor and regional lymph nodes on treatment plans in patients with advanced oral cavity squamous cell carcinoma. Int J Radiat Oncol Biol Phys 2010;77:421–9CrossRefGoogle ScholarPubMed
15Higashi, K, Ito, K, Hiramatsu, Y, Ishikawa, T, Sakuma, T, Matsunari, I et al. 18F-FDG uptake by primary tumor as a predictor of intratumoral lymphatic vessel invasion and lymph node involvement in non-small cell lung cancer: analysis of a multi-center study. Nucl Med 2005;46:267–73Google Scholar
16Nambu, A, Kato, S, Sato, Y, Okuwaki, H, Nishikawa, K, Saito, A et al. Relationship between maximum standardized uptake value (SUVmax) of lung cancer and lymph node metastasis on FDG-PET. Ann Nucl Med 2009;23:269–75CrossRefGoogle ScholarPubMed
17Maeda, R, Isowa, N, Onuma, H, Miura, H, Harada, T, Touge, H et al. The maximum standardized 18F-fluorodeoxyglucose uptake on positron emission tomography predicts lymph node metastasis and invasiveness in clinical stage IA non-small cell lung cancer. Interact Cardiovasc Thorac Surg 2009;9:79–82CrossRefGoogle ScholarPubMed
18Celen, Z, Zincirkeser, S, Dirier, A. FDG PET-CT in cervical cancer: relationship between primary tumor FDG uptake and metastatic potential. Nucl Med Commun 2010;31:526–31Google Scholar
19Suzuki, K, Nishioka, T, Homma, A, Tsuchiya, K, Yasuda, M, Aoyama, H et al. Value of fluorodeoxyglucose positron emission tomography before radiotherapy for head and neck cancer: does the standardized uptake value predict treatment outcome? Jpn J Radiol 2009;27:237–42CrossRefGoogle ScholarPubMed
20Kidd, EA, Spencer, CR, Huettner, PC, Siegel, BA, Dehdashti, F, Rader, JS et al. Cervical cancer histology and tumor differentiation affect 18F-fluorodeoxyglucose uptake. Cancer 2009;115:3548–54CrossRefGoogle ScholarPubMed