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Contact endoscopy for detection of residual or recurrent disease after radiotherapy for squamous cell carcinoma of the upper aerodigestive tract

Published online by Cambridge University Press:  02 April 2020

S Kumar ,
A K Mishra ,
J R Galagali ,
A Sethi  and
A Malik
S Kumar
Affiliation:
Department of Otorhinolaryngology – Head Neck Surgery, Army College of Medical Sciences and Base Hospital, Delhi Cantt, India
A K Mishra*
Affiliation:
Department of Otorhinolaryngology – Head Neck Surgery, Army College of Medical Sciences and Base Hospital, Delhi Cantt, India
J R Galagali
Affiliation:
Department of Otorhinolaryngology – Head Neck Surgery, Army College of Medical Sciences and Base Hospital, Delhi Cantt, India
A Sethi
Affiliation:
Department of Otorhinolaryngology – Head Neck Surgery, Army College of Medical Sciences and Base Hospital, Delhi Cantt, India
A Malik
Affiliation:
Department of Pathology and Laboratory Sciences, Army College of Medical Sciences and Base Hospital, Delhi Cantt, India
*
Author for correspondence: Professor Awadhesh Kumar Mishra, Department of Otorhinolaryngology – Head Neck Surgery, Army College of Medical Sciences and Base Hospital, Delhi Cantt110010, India E-mail: buddhiprakash@rediffmail.com Fax: +91 11 25698691
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Abstract

Objective

The aim of this study was to evaluate contact endoscopy in detecting local treatment failures post-radiotherapy in squamous cell carcinoma of the upper aerodigestive tract.

Method

A total of 135 consecutive patients with suspected residual or recurrent cancer after definitive radiotherapy underwent contact endoscopy before biopsy. Contact endoscopy findings were compared with histopathological examination findings. Contact endoscopy could not be completed in 7 patients (5.9 per cent) and histopathological examination was inconclusive in 5 patients (3.7 per cent). The findings of the remaining 123 patients were compared.

Results

The sensitivity, specificity and accuracy of contact endoscopy were 88.75, 88.72 and 86.99 per cent, respectively, with similar results across various sites of upper aerodigestive tract. Inter-observer kappa value was 0.86 (95 per cent confidence interval: 0.79–0.93). The intra-observer kappa value was 0.93 (95 per cent confidence interval: 0.87–1.00) for the first observer and 0.95 (95 per cent confidence interval: 0.90–1.00) for second and third observers.

Conclusion

Contact endoscopy showed the same high sensitivity and specificity with low inter- and intra-observer variability in detecting post-radiotherapy failures in cancer of the upper aerodigestive tract as has been shown in non-irradiated tissues in earlier studies.

Keywords

EndoscopyTreatment FailureCarcinomaSquamous CellObserver Variation
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 134 , Issue 4 , April 2020 , pp. 344 - 349
Copyright
Copyright © JLO (1984) Limited, 2020

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Footnotes

Professor A K Mishra takes responsibility for the integrity of the content of the paper

References

Bray, F, Ferlay, J, Soerjomataram, I, Siegel, RL, Torre, LA, Jemal, A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018;68:394–424CrossRefGoogle ScholarPubMed
Kulkarni, MR. Head and neck cancer burden in India. Int J Head Neck Surg 2013;4:29–35CrossRefGoogle Scholar
Hermans, R, Pameijer, FA, Mancuso, AA, Parsons, JT, Mendenhall, WM. Laryngeal or hypopharyngeal squamous cell carcinoma: can follow-up CT after definitive radiation therapy be used to detect local failure earlier than clinical examination alone? Radiology 2000;214:683–7CrossRefGoogle ScholarPubMed
Helsen, N, Roothans, D, Van Den Heuvel, B, Van den Wyngaert, T, Van den Weyngaert, D, Carp, L et al. 18F-FDG-PET/CT for the detection of disease in patients with head and neck cancer treated with radiotherapy. PLoS One 2017;12:e0182350CrossRefGoogle ScholarPubMed
Warnecke, A, Averbeck, T, Leinung, M, Soudah, B, Wenzel, GI, Kreipe, HH et al. Contact endoscopy for the evaluation of the pharyngeal and laryngeal mucosa. Laryngoscope 2010;120:253–8CrossRefGoogle ScholarPubMed
Pelucchi, S, Bianchini, C, Travagli, M, Pastore, A. Contact endoscopy of the oral mucosa: preliminary results. Acta Otorhinolaryngol Ital 2007;27:59–61Google ScholarPubMed
Pak, MW, To, KF, Leung, SF, van Hasselt, CA. In vivo diagnosis of persistent and recurrent nasopharyngeal carcinoma by contact endoscopy. Laryngoscope 2002;112:1459–66CrossRefGoogle ScholarPubMed
Pak, MW, Vlantis, AC, Chow, S, van Hasselt, CA. How reliable is contact endoscopy of the nasopharynx in patients with nasopharyngeal cancer? Laryngoscope 2009;119:523–7CrossRefGoogle ScholarPubMed
Andrea, M, Dias, O, Santos, A. Contact endoscopy during microlaryngeal surgery: a new technique for endoscopic examination of the larynx. Ann Otol Rhinol Laryngol 1995;104:333–9CrossRefGoogle ScholarPubMed
Mishra, A, Nilakantan, A, Datta, R, Sahai, K, Singh, SP, Sethi, A. Contact endoscopy - a promising tool for evaluation of laryngeal mucosal lesions. J Laryngol Voice 2012;2:53–9CrossRefGoogle Scholar
Ramos, GHA, Tavares, MR, Dedivitis, RA, Pedruzzi, PAG, Oliveira, BV. Contact endoscopy (stomatoscopy) versus histological diagnosis of lesions of the lower lip vermilion area. Appl Cancer Res 2010;30:210–5Google Scholar
Wardrop, PJ, Sim, S, McLaren, K. Contact endoscopy of the larynx: a quantitative study. J Laryngol Otol 2000;114:437–40CrossRefGoogle ScholarPubMed
Szeto, C, Wehrli, B, Whelan, F, Franklin, J, Nichols, A, Yoo, J et al. Contact endoscopy as a novel technique in the detection and diagnosis of mucosal lesions in the head and neck: a brief review. J Oncol 2011;2011: 196302CrossRefGoogle ScholarPubMed
Saeki, N, Tsuzuki, K, Negoro, A, Nin, T, Sagawa, K, Uwa, N et al. Utility of real- time diagnosis using contact endoscopy for oral and lingual diseases. Auris Nasus Larynx 2011;38:233–9CrossRefGoogle ScholarPubMed
Mishra, AK, Nilakantan, A, Sahai, K, Datta, R, Malik, A. Contact endoscopy of mucosal lesions of oral cavity - preliminary experience. Med J Armed Forces India 2014;70:257–63CrossRefGoogle ScholarPubMed
Dowthwaite, S, Szeto, C, Wehrli, B, Daley, T, Whelan, F, Franklin, J et al. Contact endoscopy as a novel technique in the detection and diagnosis of oral cavity and oropharyngeal mucosal lesions in the head and neck. J Laryngol Otol 2014;128:147–52CrossRefGoogle ScholarPubMed
Tarnawski, W, Fraczek, M, Jelen, M, Krecicki, T, Zalesska-Krecicka, M. The role of computer-assisted analysis in the evaluation of nuclear characteristics for the diagnosis of precancerous and cancerous lesions by contact laryngoscopy. Adv Med Sci 2008;53:221–7CrossRefGoogle Scholar
Puxeddu, R, Sionis, S, Gerosa, C, Carta, F. Enhanced contact endoscopy for the detection of neoangiogenesis in tumors of the larynx and hypopharynx. Laryngoscope 2015;125:1600–6CrossRefGoogle ScholarPubMed
Carta, F, Sionis, S, Cocco, D, Gerosa, C, Ferreli, C, Puxeddu, R. Enhanced contact endoscopy for the assessment of the neoangiogenetic changes in precancerous and cancerous lesions of the oral cavity and oropharynx. Eur Arch Otorhinolaryngol 2016;273:1895–903CrossRefGoogle ScholarPubMed
Esmaeili, N, Illanes, A, Boese, A, Davaris, N, Arens, C, Friebe, M. Novel automated vessel pattern characterization of larynx contact endoscopic video images. Int J Comput Assist Radiol Surg 2019;14:1751–61CrossRefGoogle ScholarPubMed
Stefanescu, DC, Ceachir, OC, Zainea, VI, Hainarosie, M, Pietrosanu, C, Ionita, IG, Hainarosie, R. Methylene blue video contact endoscopy enhancing methods. Rev Chim 2016;67:1558–9Google Scholar
Boese, A, Illanes, A, Balakrishnan, S, Davaris, N, Arens, C, Friebe, M. Vascular pattern detection and recognition in endoscopic imaging of the vocal folds. Curr Dir Biomed Eng 2018;4:75–8CrossRefGoogle Scholar
Landis, JR, Koch, GG. The measurement of observer agreement for categorical data. Biometrics 1977;33:159–74CrossRefGoogle ScholarPubMed