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The effect of long-term antibiotic therapy upon ciliary beat frequency in chronic rhinosinusitis

Published online by Cambridge University Press:  29 June 2007

G. K. Scadding ,
V. J. Lund  and
Y. C. Darby
G. K. Scadding*
Affiliation:
Royal National Throat, Nose and Ear Hospital Trust, Gray's Inn Road, London WC1X 8DA.
V. J. Lund
Affiliation:
Royal National Throat, Nose and Ear Hospital Trust, Gray's Inn Road, London WC1X 8DA.
Y. C. Darby
Affiliation:
Royal National Throat, Nose and Ear Hospital Trust, Gray's Inn Road, London WC1X 8DA.
*
Address for correspondence: Dr G. K. Scadding, The Royal National Throat, Nose and Ear Hospital, Gray's Inn Road, London WC1X 8DA.
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Abstract

The mucociliary escalator is the first line of defence of the upper and lower respiratory tracts (Greenstone and Cole, 1985; Sleigh et al., 1988). Failure of mucociliary clearance is associated with chronic or recurrent respiratory tract infection. Ten patients with chronic rhinosinusitis underwent nasal brushings for the assessment of ciliary beat frequency. In two no beating cilia were seen; in the remainder the mean value was 9.3 Hz ± 2.3; range 6.1–12.8 Hz (n = 8).

Following three months continuous oral antibiotic therapy repeat nasal brushings demonstrated increased ciliary beat frequencies in all patients, mean value 13.7 Hz ± 1.6; range 11.5–16.3 Hz (n = 10); (p<0.001 paired t-test).

Depression of mucociliary clearance can occur secondarily to chronic infection and is improved by prolonged antibiotics.

Keywords

CiliaMucociliary clearanceRhinitisSinusitisAntibiotics
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 109 , Issue 1 , January 1995 , pp. 24 - 26
Copyright
Copyright © JLO (1984) Limited 1995

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